About this Research Topic
A healthy diet and exercise reduce the risk of developing chronic metabolic diseases. Nutrient intake and diet composition can have immediate and long-term beneficial or detrimental consequences on health, and even maternal nutrition deficiencies may have an impact on the metabolic programming and health of the child. Currently, malnutrition issues due to insufficient food availability have been largely overcome in developed countries. However, those countries begin to face another side of malnutrition, with high rates of chronic metabolic diseases often attributed to unbalanced diet and over-nutrition. The interaction between nutrition, metabolism, and gene expression is crucial for the maintenance of body homeostasis. There is an interacting relationship between nutrition and the human genome, which defines and marks the gene expression and metabolic response. This in turn may affect the individual’s health and susceptibility to disease.
With the exponential increase of nutrition-related diseases, targeted approaches are needed to provide balanced diets in parallel with the development of national preventive health systems and screening programs adapted to local needs. Dietary intake is an essential factor to consider but there is marked variation in metabolic disease development with the same dietary intake between individuals pointing toward greater complexity of interactions between genetic and environmental factors.
The aim of this Research Topic is to clarify the basic knowledge about the vital role of nutrition-related genes in various disease states and to identify new concepts that could highlight the relation between nutrition and gene expression. This may help to understand the mechanism and pathogenesis of metabolic diseases like obesity, diabetes, NAFLD and cardiovascular disease and even cancer. We welcome the submission of Original Research, Review, Mini-Review, Case Report, Hypothesis and Theory, and Perspective articles in the following areas:
• The relationships between single gene/single nutrient studied by nutrigenomics and epigenomics approaches.
• Human and animal models of human nutrition studies focused on the roles of dietary and genetic factors in complex metabolic diseases and cancer metabolism and inflammatory bowel diseases.
• How the body reacts to a diet/food? The potential molecular mechanisms of diet–gene interactions.
• How human genome reacts to nutrients and expresses disease phenotypes?
• Genetic related disorders that may be improved with nutritional correction and how?
• Genetic and environmental variables affecting individual responses to diet and lifestyle behaviors.
With the exponential increase of nutrition-related diseases, targeted approaches are needed to provide balanced diets in parallel with the development of national preventive health systems and screening programs adapted to local needs. Dietary intake is an essential factor to consider but there is marked variation in metabolic disease development with the same dietary intake between individuals pointing toward greater complexity of interactions between genetic and environmental factors.
The aim of this Research Topic is to clarify the basic knowledge about the vital role of nutrition-related genes in various disease states and to identify new concepts that could highlight the relation between nutrition and gene expression. This may help to understand the mechanism and pathogenesis of metabolic diseases like obesity, diabetes, NAFLD and cardiovascular disease and even cancer. We welcome the submission of Original Research, Review, Mini-Review, Case Report, Hypothesis and Theory, and Perspective articles in the following areas:
• The relationships between single gene/single nutrient studied by nutrigenomics and epigenomics approaches.
• Human and animal models of human nutrition studies focused on the roles of dietary and genetic factors in complex metabolic diseases and cancer metabolism and inflammatory bowel diseases.
• How the body reacts to a diet/food? The potential molecular mechanisms of diet–gene interactions.
• How human genome reacts to nutrients and expresses disease phenotypes?
• Genetic related disorders that may be improved with nutritional correction and how?
• Genetic and environmental variables affecting individual responses to diet and lifestyle behaviors.
Keywords: Malnutrition, Metabolic programming, NAFLD, Obesity, Nutrigenomics, Inflammation, Dietary intervention
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
