About this Research Topic
Dendritic cells (DCs) play a pivotal function in the interface of the innate and the adaptive immune system and dictate the immunity during leishmaniasis, including cutaneous and visceral leishmaniasis.
DCs comprise a large collection of subpopulations with different functions. They are potent antigen-presenting cells equipped with pattern recognition receptors (PRRs), able to bind molecular motifs that are particular of pathogens. The ligation of PRRs initiates signaling pathways that lead to cellular activation, changes in gene expression, and metabolism that culminates in the T-cell immunity activation.
The goal of this Research Topic is to provide a collection of manuscripts discussing the relevance of dendritic cells in the immune response development and pathogenesis of leishmaniasis. We welcome studies regarding dendritic cells in human and murine models in both cutaneous and visceral leishmaniasis.
We welcome Original Research, Review articles and other article types focusing on, but not limited to, the following subtopics:
-Different DCs subsets in leishmaniasis immunity
-Interaction of Leishmania species and DCs
-Recognition of Leishmania by DCs
-Subversion of DCs intracellular signaling pathways by Leishmania
-Crosstalk between DCs and other leukocytes
-DCs metabolism and impact on infection outcome
-Vaccines based on DCs
Keywords: dendritic cell, cutaneous leishmaniasis, visceral leishmaniasis, leishmaniasis immunology, pattern recognition receptors, T cell immunity, leukocytes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.