Research Topic

Cellular and Molecular Mechanisms of Trigeminal Neuropathic Pain

About this Research Topic

Trigeminal neuralgia (TN) is a chronic, severe facial pain condition, that mainly affects the trigeminal nerve. According to the International Pain Society (IASP) TN classification standard, TN primarily contains the following three categories: idiopathic TN, with no obvious cause; Classic TN, caused by intracranial blood vessels compressing the trigeminal nerve’s posterior root; Secondary TN, caused by infection or neurological disease, such as postherpetic trigeminal neuralgia. Many studies have revealed that cellular injury, inflammation and immunology, ion channel, central sensitization, the regulation of nerve circuit (including neuropsychological modulation) and gene expression all have played important roles in the occurrence, development and maintenance of trigeminal neuropathic pain. However, mechanisms of TN and trigeminal nerve-related maxillofacial pain disease have still not been fully elucidated. TN has the following unique clinical symptoms: arise suddenly, stop abruptly, severe pain and trigger during daily activities. Therefore, there is a probability that TN has distinct pathogenesis from other kinds of neuropathic pain. This needs to be further investigated. The advancement of research techniques, such as animal models of the trigeminal nerve, electrophysiology, neural tracer technology, optogenetics and chemical genetics, has provided great opportunities to reveal the pathogenesis of trigeminal neuralgia.

This Research Topic aims to bring together research on the molecular and cellular mechanisms of trigeminal neuralgia and trigeminal neuropathic pain, as well as to shed light on the advancement of Trigeminal neuralgia treatment. We welcome all submissions that include, but are not limited to, the following aspects:
- Study on molecular signaling pathways related to trigeminal neuropathic pain;
- The role of satellite glial cell and neuron interaction mechanisms in trigeminal neuropathic pain;
- The role of peripheral nerve sensitization and central sensitization in trigeminal neuropathic pain;
- Research on novel treatment methods for trigeminal neuralgia, including gene therapy, stem cell therapy, etc.;
- The role of the central nervous circuit in trigeminal neuropathic pain;
- The neuropsychological factors associated with trigeminal neuropathic pain;
- Neuroimmune and neuroinflammatory mechanisms associated with trigeminal neuropathic pain;
- The role of ion channels and neuronal electrophysiology in trigeminal neuropathic pain;
- The establishment of transgenic animal models for trigeminal neuropathic pain disease, translational medicine and other related research.


Keywords: Trigeminal Neuralgia, Trigeminal Neuropathic Pain, Signaling Pathway, Neuroimmune, Neuroinflammatory


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Trigeminal neuralgia (TN) is a chronic, severe facial pain condition, that mainly affects the trigeminal nerve. According to the International Pain Society (IASP) TN classification standard, TN primarily contains the following three categories: idiopathic TN, with no obvious cause; Classic TN, caused by intracranial blood vessels compressing the trigeminal nerve’s posterior root; Secondary TN, caused by infection or neurological disease, such as postherpetic trigeminal neuralgia. Many studies have revealed that cellular injury, inflammation and immunology, ion channel, central sensitization, the regulation of nerve circuit (including neuropsychological modulation) and gene expression all have played important roles in the occurrence, development and maintenance of trigeminal neuropathic pain. However, mechanisms of TN and trigeminal nerve-related maxillofacial pain disease have still not been fully elucidated. TN has the following unique clinical symptoms: arise suddenly, stop abruptly, severe pain and trigger during daily activities. Therefore, there is a probability that TN has distinct pathogenesis from other kinds of neuropathic pain. This needs to be further investigated. The advancement of research techniques, such as animal models of the trigeminal nerve, electrophysiology, neural tracer technology, optogenetics and chemical genetics, has provided great opportunities to reveal the pathogenesis of trigeminal neuralgia.

This Research Topic aims to bring together research on the molecular and cellular mechanisms of trigeminal neuralgia and trigeminal neuropathic pain, as well as to shed light on the advancement of Trigeminal neuralgia treatment. We welcome all submissions that include, but are not limited to, the following aspects:
- Study on molecular signaling pathways related to trigeminal neuropathic pain;
- The role of satellite glial cell and neuron interaction mechanisms in trigeminal neuropathic pain;
- The role of peripheral nerve sensitization and central sensitization in trigeminal neuropathic pain;
- Research on novel treatment methods for trigeminal neuralgia, including gene therapy, stem cell therapy, etc.;
- The role of the central nervous circuit in trigeminal neuropathic pain;
- The neuropsychological factors associated with trigeminal neuropathic pain;
- Neuroimmune and neuroinflammatory mechanisms associated with trigeminal neuropathic pain;
- The role of ion channels and neuronal electrophysiology in trigeminal neuropathic pain;
- The establishment of transgenic animal models for trigeminal neuropathic pain disease, translational medicine and other related research.


Keywords: Trigeminal Neuralgia, Trigeminal Neuropathic Pain, Signaling Pathway, Neuroimmune, Neuroinflammatory


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

10 August 2021 Abstract
08 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

10 August 2021 Abstract
08 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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