About this Research Topic
Protein misfolding associated neurodegenerative diseases affect millions of people worldwide. Despite the enormous progress made in science, technology, innovation as well as in our current understanding about the factors that trigger proteinopathies, there are no cures or effective remedies available to treat these disorders. The currently available therapies are primarily for patients that show disease symptoms and only provide limited improvements. Although modern approaches offer great promises in this aspect the translational research, however, faces lots of challenges when considering extrapolating the laboratory findings to the final stages of drug development or making the drug available for clinical use. One of the hallmarks of these neurodegenerative disorders is the death of neurons, possibly due to the aggregation of misfolded proteins and/or altered cellular or molecular functions. This further worsens the disease condition as neurons are post-mitotic in nature and cannot enter the cell cycle again. There is an urgent need for the development of therapeutics (or disease-modifying therapies) that can hinder cell death, inhibit/ block or delay the onset or progression of these deadly diseases.
This Research Topic aims to help understand the precise cellular and molecular mechanisms (such as impaired protein quality control or defective post-translational modifications) that are altered and contribute towards causing these diseases. Understanding the underlying cellular and molecular mechanisms may help in the development of potential therapeutic targets or novel biomarkers (which may possibly detect diseases at early stages) to treat these devastating disorders. This Research Topic will aid in connecting the missing links, discerning the gaps, upgrading our current understanding and knowledge on the development of cheap, efficient, reliable, and better therapeutics that may alone, or in combination with other therapies, effectively treat these neurodegenerative diseases and prove to be clinically beneficial.
We thereby seek and welcome contributions of original research articles, reviews, methods, or mini-reviews that uncover the molecular and/or cellular mechanisms underlying protein misfolding associated neurodegenerative diseases.
More examples of the mechanisms which may be altered or contribute towards protein misfolding and diseases include:
1. Genetic mutations,
2. Increase in oxidative stress,
3. Aberrant cell-cell signaling,
4. Mitochondrial dysfunction etc.
Keywords: In vitro, in vivo models, protein misfolding, proteinopathies, cellular and molecular disease mechanisms, neurodegeneration, cell death, neurodegenerative diseases, therapies, therapeutic approaches, therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.