About this Research Topic
Vitamin D and is an essential nutrient, and its metabolites regulate calcium homeostasis but also have other increasingly recognized physiologic roles. When Vitamin D metabolism or intake is disrupted, these physiologic roles may be perturbed, leading to or contributing to disease. In domestic animals, reduced circulating concentrations of vitamin D are linked to critical illness, infectious diseases, heart failure, inflammatory and immune mediated diseases, and cancer. Vitamin D plays an important role in modulating immune defenses and regulation. This Research Topic aims to explore the roles of Vitamin D diseases of veterinary species beyond its role in calcium homeostasis.
Much remains unknown about the role of vitamin D metabolites in various diseases and the mechanisms through which they may cause or contribute to disease. We seek studies that evaluate vitamin concentrations in disease, explore the molecular mechanisms relative to Vitamin D signaling, or modify Vitamin D intake while measuring physiologic or pathophysiologic outcomes. The primary focus of these investigations should not be evaluating the role of Vitamin D metabolism in mineral homeostasis. Studies that emphasize the role of Vitamin D in immune homeostasis are preferred. Such studies will augment the current body of knowledge on the subject and identify new avenues for continued investigation.
Potential topics for submissions include, but are not limited to:
- Evaluations of Vitamin D intake relative to defined parameters or outcomes in veterinary species.
- Descriptions of Vitamin D status (e.g., blood concentrations of Vitamin D metabolites) in veterinary disease states.
- Molecular changes associated with changes in Vitamin D concentrations in vivo or in vitro.
- Understanding how Vitamin D metabolism is modulated, e.g., changes in CYP enzymes or renal clearance.
Keywords: Vitamin D, calcitriol, vitamin D receptor, metabolism, disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.