About this Research Topic
Diabetes and osteoporosis are both frequent disorders and both are increasing in prevalence. Disturbances in bone turnover, biomechanical competence is prevalent in both type 1 and type 2 diabetes, and contrary to changes in bone density an increased risk of fractures may be seen in diabetes, especially T1D.
Bone biomechanical competence is compromised in diabetes, and the mechanisms are not fully understood and data on management are sparse. Along these lines, the topic aims to elucidate: 1) Changes in bone turnover, 2) changes in bone structure, density and biomechanical competence, 3) Epidemiology of fractures in diabetes, and 4) Results of clinical studies on bone in diabetes.
The papers should be based on original data from basal and clinical as well as epidemiological studies on bone in type 1 and type 2 diabetes.
Examples of article titles include:
-The effect of protein supplements on markers of bone turnover in pre-diabetic adults
-Bone structure and bone turnover markers in males with metabolic syndrome and males with diabetes
-Associations between Abdominal aortic calcified score and bone turnover markers in patients with diabetes
-Alendronate use and risk of type 2 diabetes: a Danish population-based case-control study
-Biphosphonate or denosumab as osteoporotic treatment in patients with diabetes
-Changes in osteoglycin levels during fasing, oral glucose ingestion and intravenous isoglycemic glucose infusion
-Changes in ketones, PTH and bone turnover during fasting and oral glucose ingestion
-The risk of osteoporotic fractures with SGLT-2 inhibitors compared to GLP-1 receptor agonists as add-on therapies to metformin
-The risk of osteoporotic fractures with GLP-1 receptor agonists compared to DPP-IV inhibitors as add-on therapies to metformin
-Bone turnover markers depend on insulin sensitivity in treatment naïve T2D patients
-HRpQCT in T2D
-Prevalent fractures in T2D
Conflict of interest: Prof. Peter Vestergaard is head of research at Steno Diabetes Center North Jutland funded by the Novo Nordisk Foundation
Bone biomechanical competence is compromised in diabetes, and the mechanisms are not fully understood and data on management are sparse. Along these lines, the topic aims to elucidate: 1) Changes in bone turnover, 2) changes in bone structure, density and biomechanical competence, 3) Epidemiology of fractures in diabetes, and 4) Results of clinical studies on bone in diabetes.
The papers should be based on original data from basal and clinical as well as epidemiological studies on bone in type 1 and type 2 diabetes.
Examples of article titles include:
-The effect of protein supplements on markers of bone turnover in pre-diabetic adults
-Bone structure and bone turnover markers in males with metabolic syndrome and males with diabetes
-Associations between Abdominal aortic calcified score and bone turnover markers in patients with diabetes
-Alendronate use and risk of type 2 diabetes: a Danish population-based case-control study
-Biphosphonate or denosumab as osteoporotic treatment in patients with diabetes
-Changes in osteoglycin levels during fasing, oral glucose ingestion and intravenous isoglycemic glucose infusion
-Changes in ketones, PTH and bone turnover during fasting and oral glucose ingestion
-The risk of osteoporotic fractures with SGLT-2 inhibitors compared to GLP-1 receptor agonists as add-on therapies to metformin
-The risk of osteoporotic fractures with GLP-1 receptor agonists compared to DPP-IV inhibitors as add-on therapies to metformin
-Bone turnover markers depend on insulin sensitivity in treatment naïve T2D patients
-HRpQCT in T2D
-Prevalent fractures in T2D
Conflict of interest: Prof. Peter Vestergaard is head of research at Steno Diabetes Center North Jutland funded by the Novo Nordisk Foundation
Keywords: Diabetes, Bone, Turnover, Type 1 Diabetes, Type 2 Diabetes
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