About this Research Topic
Bacterial infections are among the leading causes of death worldwide. The emergence of antimicrobial resistance factors threaten the efficacy of all current antimicrobial agents, with some already made ineffective, and, as a result, there is an urgent need for new treatment approaches. International organizations such as the World Health Organization and the European Centre for Diseases Control have recognized infections caused by multi-drug-resistant (MDR) bacteria as a priority for global health action, and new policies and actions are needed to avoid the predicted figures for 2050 of 10 million deaths caused by MDR bacteria.
Classical antimicrobial drug discovery involves in vitro screening for antimicrobial candidates, Structure Activity Relationship (SAR) analysis, followed by in vivo testing for toxicity. Bringing drugs from the bench to the bedside involves huge expenditures in time and resources. This, along with the relatively short window of therapeutic application for antibiotics attributed to the rapid emergence of drug resistance, has, at least until recently, resulted in a waning interest in antibiotic discovery among pharmaceutical companies. In this environment, “re-purposing” (defined as investigating new uses for existing approved drugs) has gained renewed interest, as reflected by several recent studies, and may help to speed up the drug development process and save years of expensive research invested in antimicrobial drug development.
The goal of this Research Topic is to systematically provide an overview of the scientific evidence on potential non-antimicrobial treatments (including phages or derivates) targeting bacteria. Specifically, we aim to: i) list potential approved drugs with antibacterial activities, identified from drug screens ii) review their mechanism of action against bacteria and their pharmacokinetics and safety properties, iii) summarize the outcome of pre-clinical and clinical trials investigating approved drugs targeting these pathogens and iv) association of non-antimicrobial treatments and antimicrobial treatments.
We welcome researchers to submit reviews, opinions, or original research focusing on drug re-purposing treatment against bacteria and viruses
This is a continuation of the the previous Research Topic: Drug Re-Purposing for the Treatment of Bacterial and Viral Infections (https://www.frontiersin.org/research-topics/7730/drug-re-purposing-for-the-treatment-of-bacterial-and-viral-infections)
Keywords: bacterial infections, antimicrobials, drug re-purposing, antimicrobial resistance
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