About this Research Topic
In 1979, Andreas Gruntzig first demonstrated the use of coronary physiology to evaluate the impact of percutaneous coronary intervention (PCI). Since then, intra-coronary physiology has evolved to become a key cornerstone of contemporary PCI practice, and its use is now firmly established in the latest guidelines on myocardial revascularization.
Over the last decade, technological improvements and new devices have fueled a dramatic expansion in our knowledge of coronary physiology, its potential applications and its impact upon clinical outcomes. In addition to fractional flow reserve (FFR), the development of novel hyperaemic and non-hyperaemic indices (NHRI) as well as the ability to evaluate the microcirculation have opened new avenues for basic science and clinical research.
There is now a growing body of evidence supporting the use of intra-coronary physiology to guide all aspects of a PCI procedure. At the start of the procedure, intra-coronary physiology is recommended to assess the severity of lesions with an angiographic severity <90%. During the PCI, ‘virtual PCI’ can be performed using physiological assessments to guide the optimal revascularization strategy. At the end of the procedure, post-PCI physiology can be used to assess the impact of the intervention, identify sub-optimal results and can be used to determine long-term prognosis.
This expansion in the clinical application of intra-coronary physiology has generated many scientific and clinical questions which remain un-resolved. Therefore, the aim of this research topic is to seek out and provide answers to many of the key issues and even controversies regarding intra-coronary physiology. Furthermore, current and emerging technologies and physiological indices as well as novel applications of intra-coronary physiology in clinical practice will be presented.
We welcome Original Research, Review, Mini Review, Methodology Papers and Case Report articles on all aspects of intra-coronary physiology in PCI including (but not limited to):
• Improving the reliability of lesion severity assessment
• Lesion severity assessment in complex subsets: acute coronary syndromes, valvular heart diseases, coronary artery bypass grafts, chronic total occlusions.
• Use of physiology to evaluate non-culprit lesions following acute coronary syndromes.
• Understanding pathophysiological basis for discordance between hyperaemic and non-hyperaemic indices
• Physiology guided planning of PCI
• Illustrative cases highlighting the uses and pitfalls of intracoronary physiology
Over the last decade, technological improvements and new devices have fueled a dramatic expansion in our knowledge of coronary physiology, its potential applications and its impact upon clinical outcomes. In addition to fractional flow reserve (FFR), the development of novel hyperaemic and non-hyperaemic indices (NHRI) as well as the ability to evaluate the microcirculation have opened new avenues for basic science and clinical research.
There is now a growing body of evidence supporting the use of intra-coronary physiology to guide all aspects of a PCI procedure. At the start of the procedure, intra-coronary physiology is recommended to assess the severity of lesions with an angiographic severity <90%. During the PCI, ‘virtual PCI’ can be performed using physiological assessments to guide the optimal revascularization strategy. At the end of the procedure, post-PCI physiology can be used to assess the impact of the intervention, identify sub-optimal results and can be used to determine long-term prognosis.
This expansion in the clinical application of intra-coronary physiology has generated many scientific and clinical questions which remain un-resolved. Therefore, the aim of this research topic is to seek out and provide answers to many of the key issues and even controversies regarding intra-coronary physiology. Furthermore, current and emerging technologies and physiological indices as well as novel applications of intra-coronary physiology in clinical practice will be presented.
We welcome Original Research, Review, Mini Review, Methodology Papers and Case Report articles on all aspects of intra-coronary physiology in PCI including (but not limited to):
• Improving the reliability of lesion severity assessment
• Lesion severity assessment in complex subsets: acute coronary syndromes, valvular heart diseases, coronary artery bypass grafts, chronic total occlusions.
• Use of physiology to evaluate non-culprit lesions following acute coronary syndromes.
• Understanding pathophysiological basis for discordance between hyperaemic and non-hyperaemic indices
• Physiology guided planning of PCI
• Illustrative cases highlighting the uses and pitfalls of intracoronary physiology
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
