Research Topic

Neuro-Immune Interactions and Neuroinflammation in Neurocritical Care

About this Research Topic

Neurocritical care is an interdisciplinary discipline of neurology and critical care medicine, and the establishment of neuro-intensive care unit has improved the survival and functional outcome of neurocritically ill patients. The peculiarity of neurocritically ill patients lies in the fact that in addition to severe brain injury, they are often accompanied by other organ dysfunction, and there is an interaction between brain injury and peripheral organ injury. Understanding the relationship between severe brain injury and other organ injuries may help us to better manage patients and improve patient outcomes. Immune and inflammatory responses play an important role in brain and other organ damage, and may be an important bridge connecting the brain and other organs. Excessive immune response in the early stage of severe brain injury can aggravate brain injury by causing neuroinflammation, while insufficient immune response (immunosuppression) may make the body vulnerable to pathogen attack. Only proper regulation of the immune state of neurocritically ill patients can provide optimal management. Furthermore, many immune-related indicators in blood and cerebrospinal fluid can effectively reflect the immune status of patients and even provide important prognostic information.

In this Research Topic, we aim to shed light on the role of neuroimmunity, neuroinflammation, and autonomic nervous system in secondary injury after severe brain injury, and to explore the role of these factors in the crosstalk between severe brain injury and other organ injuries. In addition, we also focus on the role of neuroimmune-related biomarkers in assessing the status of immune function and predicting the prognosis of neurocriticlally ill patients. We welcome submissions of Reviews, Mini Reviews, Original Research articles, and Clinical Trials that cover, but are not limited to, the following subtopics:

• The role of neuroimmunity, neuroinflammation, and autonomic nervous system in secondary injury after severe brain injury.
• The role and biomarkers of neuroimmunity, neuroinflammation, and autonomic nervous system in cerebral edema and blood brain barrier disruption.
• Peripheral organ damage after severe brain injury associated with neuroimmunity, neuroinflammation, and the autonomic nervous system.
• Mechanisms of peripheral organ injury exacerbating severe brain injury involving intestinal-brain axis, lung-brain axis, kidney-brain axis, etc.
• Data on new molecular and immunological treatments in neurocritical care.
• Neuroimmune-related biomarkers in assessing the status of immune function and predicting the prognosis of neurocriticlally ill patients.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurocritical care is an interdisciplinary discipline of neurology and critical care medicine, and the establishment of neuro-intensive care unit has improved the survival and functional outcome of neurocritically ill patients. The peculiarity of neurocritically ill patients lies in the fact that in addition to severe brain injury, they are often accompanied by other organ dysfunction, and there is an interaction between brain injury and peripheral organ injury. Understanding the relationship between severe brain injury and other organ injuries may help us to better manage patients and improve patient outcomes. Immune and inflammatory responses play an important role in brain and other organ damage, and may be an important bridge connecting the brain and other organs. Excessive immune response in the early stage of severe brain injury can aggravate brain injury by causing neuroinflammation, while insufficient immune response (immunosuppression) may make the body vulnerable to pathogen attack. Only proper regulation of the immune state of neurocritically ill patients can provide optimal management. Furthermore, many immune-related indicators in blood and cerebrospinal fluid can effectively reflect the immune status of patients and even provide important prognostic information.

In this Research Topic, we aim to shed light on the role of neuroimmunity, neuroinflammation, and autonomic nervous system in secondary injury after severe brain injury, and to explore the role of these factors in the crosstalk between severe brain injury and other organ injuries. In addition, we also focus on the role of neuroimmune-related biomarkers in assessing the status of immune function and predicting the prognosis of neurocriticlally ill patients. We welcome submissions of Reviews, Mini Reviews, Original Research articles, and Clinical Trials that cover, but are not limited to, the following subtopics:

• The role of neuroimmunity, neuroinflammation, and autonomic nervous system in secondary injury after severe brain injury.
• The role and biomarkers of neuroimmunity, neuroinflammation, and autonomic nervous system in cerebral edema and blood brain barrier disruption.
• Peripheral organ damage after severe brain injury associated with neuroimmunity, neuroinflammation, and the autonomic nervous system.
• Mechanisms of peripheral organ injury exacerbating severe brain injury involving intestinal-brain axis, lung-brain axis, kidney-brain axis, etc.
• Data on new molecular and immunological treatments in neurocritical care.
• Neuroimmune-related biomarkers in assessing the status of immune function and predicting the prognosis of neurocriticlally ill patients.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 August 2021 Abstract
13 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 August 2021 Abstract
13 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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