About this Research Topic
Cellular signal transduction is essential in most physiological processes and disorders. Despite the huge variability of molecules involved in signal transduction, there are common mechanisms to all signalling pathways that modulate cells response such as the availability and distribution of signal receptors or the rate and efficiency with which signals travel across the cell. These are highly influenced by the structure and plasticity of the plasma membrane and the cellular cortex that, through nano- and micro-arrangements of the cell membrane, determine how signals are transmitted across the plasma membrane and inside the cell, and how those signals are amplified from the initial stimuli to the target molecule or organelle.
Lipids have a direct impact on protein distribution at the plasma membrane, lateral mobility of proteins and other molecules, and modulating actin dynamics. Likewise, cytoskeletal proteins such as filamentous actin and actin regulators can aid or confine molecular mobility at the membrane and influence lipid metabolism. Both, membrane lipids and the cytoskeleton interact and cooperate as sensors and transductors in cell signalling through continuous feedback, however, this dynamic interplay can occur so fast that dissecting the contribution of each component on signalling has been extremely challenging. Yet, novel advances have allowed studying lipids in live cells and better examining molecular dynamics providing growing evidence of the importance that the lipid composition and ultrastructure of the plasma membrane and the cellular cortex have in signal transduction.
This Research Topic aims to gather a comprehensive collection of articles from a variety of fields (from cell biology, biochemistry to biophysics) focused on/covering emerging research on the interactions between the lipids of the plasma membrane and the cytoskeleton that shape signal transduction. We welcome original research articles, technical/methodological advances and reviews. The scope of the collection will include:
• Molecular interactions that connect the plasma membrane and the cortical cytoskeleton during signal transduction.
• Molecular dynamics at the plasma membrane and the cell cortex in response to cell stimulation.
• Advances on the ultrastructure of the plasma membrane and cell cortex that influence signal transduction.
• New/improved techniques contributing to the study of molecular dynamics and interactions between the plasma membrane and the cell cortex.
• Computational modelling studies addressing the interplay between the plasma membrane and the cell cortex.
Keywords: Signal Transduction, Plasma Membrane, Cytoskeleton, Disorders, Computational Modeling, Omics Studies, Molecular Dynamics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.