Research Topic

Macrophage Differentiation and Activation in the Gut and Influence in Inflammatory Bowel Disease

About this Research Topic

Emerging evidence has shown a causal link between macrophage alteration and the onset of inflammatory bowel disease (IBD), proposing that macrophages could be a potential therapeutic target. However, macrophages show high heterogeneity and plasticity, their regulation mechanisms are complicated, and the role of the macrophage in IBD pathogenesis is unclear. The diverse origin of macrophage populations, the complex environmental and tissue factors, together with the unique genetic predisposition of each human individual, make this scientific field more exciting but also challenging. Cutting-edge technologies have contributed substantially to our understanding of tissue-specific macrophage function in IBD. Therefore, recruiting new studies in this unique topic collection will largely contribute to the macrophage and IBD community and benefit the target exploration.

Tissue macrophages as a therapeutic target for IBD are promising but largely unknown on the regulation mechanisms. We aim to collect more elegant studies to deepen our understanding of macrophage biology and IBD pathogenesis. We will focus on further clarifying the role of the macrophages in the gut, demonstrating macrophage plasticity in the gut, and will identifying mechanisms in macrophage activation in the gut, and all based on the setting to IBD, especially some specific immune pathways related to macrophages.

In this Research Topic, we welcome the submission of Original Research, Review, and Mini-Review articles, which cover, but are not limited to, the following subtopics:

1. Macrophage populations identified within the gut (or/and identified in blood as well) in healthy versus CD/UC patients

2. The relationship of transcriptomic, proteomics, and metabolomics and these macrophage population's activation/differentiation in the gut, and specifically in IBD

3. Factors that affect macrophage differentiation/activation such as the environment, including the microbiota

4. Interaction of macrophage with stem cell, endothelial cell, and neurons within the gut

5. Interaction of macrophage and T cells in IBD pathogenesis, IBD relapse, fibrosis and cancer

6. The use of cutting-edge technologies in improving our understanding of macrophage heterogeneity and plasticity in gut homeostasis and IBD


Keywords: Macrophage differentiation and polarization, microbiota, metabolism, epigenetics, macrophage heterogeneity and plasticity, IBD, inflammatory bowel disease, therapeutic target


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Emerging evidence has shown a causal link between macrophage alteration and the onset of inflammatory bowel disease (IBD), proposing that macrophages could be a potential therapeutic target. However, macrophages show high heterogeneity and plasticity, their regulation mechanisms are complicated, and the role of the macrophage in IBD pathogenesis is unclear. The diverse origin of macrophage populations, the complex environmental and tissue factors, together with the unique genetic predisposition of each human individual, make this scientific field more exciting but also challenging. Cutting-edge technologies have contributed substantially to our understanding of tissue-specific macrophage function in IBD. Therefore, recruiting new studies in this unique topic collection will largely contribute to the macrophage and IBD community and benefit the target exploration.

Tissue macrophages as a therapeutic target for IBD are promising but largely unknown on the regulation mechanisms. We aim to collect more elegant studies to deepen our understanding of macrophage biology and IBD pathogenesis. We will focus on further clarifying the role of the macrophages in the gut, demonstrating macrophage plasticity in the gut, and will identifying mechanisms in macrophage activation in the gut, and all based on the setting to IBD, especially some specific immune pathways related to macrophages.

In this Research Topic, we welcome the submission of Original Research, Review, and Mini-Review articles, which cover, but are not limited to, the following subtopics:

1. Macrophage populations identified within the gut (or/and identified in blood as well) in healthy versus CD/UC patients

2. The relationship of transcriptomic, proteomics, and metabolomics and these macrophage population's activation/differentiation in the gut, and specifically in IBD

3. Factors that affect macrophage differentiation/activation such as the environment, including the microbiota

4. Interaction of macrophage with stem cell, endothelial cell, and neurons within the gut

5. Interaction of macrophage and T cells in IBD pathogenesis, IBD relapse, fibrosis and cancer

6. The use of cutting-edge technologies in improving our understanding of macrophage heterogeneity and plasticity in gut homeostasis and IBD


Keywords: Macrophage differentiation and polarization, microbiota, metabolism, epigenetics, macrophage heterogeneity and plasticity, IBD, inflammatory bowel disease, therapeutic target


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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