Research Topic

Role of Flavonoids on Microbiota–Gut–Brain Axis and on Neurodegenerative Diseases

About this Research Topic

The microbiota-gut-brain axis encompasses the strong bidirectional communication between the gut microbiota and the central nervous system (CNS). Increasing evidence suggests that abnormalities in the brain-gut-microbiota axis play a role in the pathogenesis of several neurological and neurodegenerative diseases. It has been shown that the gut microbiota can influence neurodevelopment, modulate behavior, and contribute to the development of neurological disorders.

Knowing that diet is an important factor that can rapidly induce changes in gut microbiota composition, the emerging epidemic of chronic degenerative non communicable diseases, such as neurodegenerative diseases, have motivated the research on natural products able to counteract these pathologies. In this perspective anthocyanins, that we ingest with food daily, represent one of the most attractive categories of bioactive molecules. Based on the evidence from the literature, anthocyanins play a role in the prevention and treatment of negative health outcomes significantly affecting the aging population including neurodegenerative diseases. Anthocyanin derived metabolites from the microbiome have been suggested to contribute to their positive biological effects. Therefore, the role of the gut microbiome to mediate the effects of anthocyanins is of interest.

Authors are invited to submit manuscripts which focus on any aspect related to the relationship among anthocyanins, microbiota–gut–brain axis and neurodegenerative diseases.


Keywords: Anthocyanins, Antioxidant, Biological activity, Functional foods, Nutraceuticals, Microbiota, Microbiota–gut–brain axis, Neurodegenerative diseases, Absorption and metabolism, Inflammation, Phenolic metabolites


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The microbiota-gut-brain axis encompasses the strong bidirectional communication between the gut microbiota and the central nervous system (CNS). Increasing evidence suggests that abnormalities in the brain-gut-microbiota axis play a role in the pathogenesis of several neurological and neurodegenerative diseases. It has been shown that the gut microbiota can influence neurodevelopment, modulate behavior, and contribute to the development of neurological disorders.

Knowing that diet is an important factor that can rapidly induce changes in gut microbiota composition, the emerging epidemic of chronic degenerative non communicable diseases, such as neurodegenerative diseases, have motivated the research on natural products able to counteract these pathologies. In this perspective anthocyanins, that we ingest with food daily, represent one of the most attractive categories of bioactive molecules. Based on the evidence from the literature, anthocyanins play a role in the prevention and treatment of negative health outcomes significantly affecting the aging population including neurodegenerative diseases. Anthocyanin derived metabolites from the microbiome have been suggested to contribute to their positive biological effects. Therefore, the role of the gut microbiome to mediate the effects of anthocyanins is of interest.

Authors are invited to submit manuscripts which focus on any aspect related to the relationship among anthocyanins, microbiota–gut–brain axis and neurodegenerative diseases.


Keywords: Anthocyanins, Antioxidant, Biological activity, Functional foods, Nutraceuticals, Microbiota, Microbiota–gut–brain axis, Neurodegenerative diseases, Absorption and metabolism, Inflammation, Phenolic metabolites


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

16 August 2021 Abstract
14 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

16 August 2021 Abstract
14 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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