Research Topic

Analytical Methodology for the Detection of Clinical Volatile Organic Compounds (VOCs) for Biomedical Applications

About this Research Topic

Clinical Volatile Organic Compounds (VOCs) have generated increasing interest in biomedical research as they play a vital role in developing diagnostics, prognosis, and therapeutics for a disease or indisposition. VOCs may be an endogenous product of metabolic processes, or produced due to an extraneous challenge such as the presence of microbial population or pollutants. Emerging analytical methodology for collecting, preconcentrating, and analyzing VOCs allows us to detect a comprehensive list of clinical VOCs and provide a confident identification of the VOCs sample from different health statuses. Associating chemical knowledge of VOCs with the cellular mechanism and leveraging that understanding to develop new biomedical applications is a promising topic within analytical chemistry.

VOCs represent a diverse chemical group of compounds that are volatile at normal room temperature and typically have a characteristic odor. They are present in different biological matrices such as urine, blood, feces, or breath, and are detectable using analytical methodologies. There are multiple analytical challenges with VOC analysis, 1) collection and storage of trace levels of VOCs from clinical samples 2) sample preparation and preconcentration 3) analysis of VOCs using analytical techniques including HPLC, GC, and Comprehensive Chromatography like LC×LC or GC×GC, 4) detection of VOCs by high-resolution mass spectrometry or chemical-sensing devices such as e-nose and 5) chemometric methods for analysis of the large volume of the VOCs metabolites. Recent research has shown advances in clinical VOC studies. Addressing the issues above poses the latest evolving topic in this field. The aim of this Research Topic is to become the reference point for solutions with regards to those aspects, providing a guide for VOC analysis in biomedical applications.

We welcome submissions of Original Research and Review articles, in themes including, but not limited to:

 • Novel analytical methodologies concerning VOCs collection processes, trapping and concentrating process of VOCs, storage, transport of VOCs and other related challenges.
 • Sample preparation methodology development involving thermal desorption or headspace or solid phase microextraction and related technologies
 • Analytical method development dealing with VOC analysis using chromatographic techniques such as GC, HPLC, LC×LC or GC×GC or e-nose
 • Analytical method development for VOC detection using techniques such as TOF MS, MS/MS, high resolution MS, PTRMS
 • Chemometric and data analysis and related technologies such as normalization, unsupervised, supervised analysis and machine learning, artificial intelligence


Keywords: VOCs, volatile organic compounds, chemical biomarkers, biomarkers, mass spectrometry, bioanalytical methodology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Clinical Volatile Organic Compounds (VOCs) have generated increasing interest in biomedical research as they play a vital role in developing diagnostics, prognosis, and therapeutics for a disease or indisposition. VOCs may be an endogenous product of metabolic processes, or produced due to an extraneous challenge such as the presence of microbial population or pollutants. Emerging analytical methodology for collecting, preconcentrating, and analyzing VOCs allows us to detect a comprehensive list of clinical VOCs and provide a confident identification of the VOCs sample from different health statuses. Associating chemical knowledge of VOCs with the cellular mechanism and leveraging that understanding to develop new biomedical applications is a promising topic within analytical chemistry.

VOCs represent a diverse chemical group of compounds that are volatile at normal room temperature and typically have a characteristic odor. They are present in different biological matrices such as urine, blood, feces, or breath, and are detectable using analytical methodologies. There are multiple analytical challenges with VOC analysis, 1) collection and storage of trace levels of VOCs from clinical samples 2) sample preparation and preconcentration 3) analysis of VOCs using analytical techniques including HPLC, GC, and Comprehensive Chromatography like LC×LC or GC×GC, 4) detection of VOCs by high-resolution mass spectrometry or chemical-sensing devices such as e-nose and 5) chemometric methods for analysis of the large volume of the VOCs metabolites. Recent research has shown advances in clinical VOC studies. Addressing the issues above poses the latest evolving topic in this field. The aim of this Research Topic is to become the reference point for solutions with regards to those aspects, providing a guide for VOC analysis in biomedical applications.

We welcome submissions of Original Research and Review articles, in themes including, but not limited to:

 • Novel analytical methodologies concerning VOCs collection processes, trapping and concentrating process of VOCs, storage, transport of VOCs and other related challenges.
 • Sample preparation methodology development involving thermal desorption or headspace or solid phase microextraction and related technologies
 • Analytical method development dealing with VOC analysis using chromatographic techniques such as GC, HPLC, LC×LC or GC×GC or e-nose
 • Analytical method development for VOC detection using techniques such as TOF MS, MS/MS, high resolution MS, PTRMS
 • Chemometric and data analysis and related technologies such as normalization, unsupervised, supervised analysis and machine learning, artificial intelligence


Keywords: VOCs, volatile organic compounds, chemical biomarkers, biomarkers, mass spectrometry, bioanalytical methodology


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

14 September 2021 Abstract
14 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

14 September 2021 Abstract
14 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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