Research Topic

Antioxidant Compounds in Central Nervous System Diseases: New Approaches and Pharmaceutical Potential

About this Research Topic

Oxidative stress is one of the major pathomechanisms playing a crucial role in the development and progression of CNS diseases, including stroke, epilepsy, and neurodegenerative disorders. In many cases, the causal relationship is not established whether it is a cause or a consequence of the disease, but therapies largely benefit from any action at mitigating oxidative stress.

The goal of this Research Topic is to collect advanced research contributions on the connection between oxidative stress and diseases, particularly CNS pathologies and the pharmaceutical potential of compounds with antioxidant properties. This encompasses clinical, experimental, and modeling results related to physiological and biological insights, novel pharmaceutical preparations as well as repurposing, with a special focus on natural supplements and products, clinical and pre-clinical reports.

This collection is inherently interdisciplinary because health problems involve not only medicine and medicinal chemistry, but in the modern holistic conception, essential contributions come from biological, biotechnological, and pharmaceutical research as well as from physics and chemistry.

Contributions to this Research Topic ideally deal, although not exclusively, with:

- Modeling molecules and biomolecules showing antioxidant activity.

- Antioxidant enzymes, mimics, and drugs with therapeutic potential in CNS diseases.

- Endogenous, synthetic, or natural antioxidant compounds with therapeutic potential in CNS diseases.


Keywords: oxidative stress, drug delivery systems for antioxidants, antioxidant molecules, CNS diseases, modeling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Oxidative stress is one of the major pathomechanisms playing a crucial role in the development and progression of CNS diseases, including stroke, epilepsy, and neurodegenerative disorders. In many cases, the causal relationship is not established whether it is a cause or a consequence of the disease, but therapies largely benefit from any action at mitigating oxidative stress.

The goal of this Research Topic is to collect advanced research contributions on the connection between oxidative stress and diseases, particularly CNS pathologies and the pharmaceutical potential of compounds with antioxidant properties. This encompasses clinical, experimental, and modeling results related to physiological and biological insights, novel pharmaceutical preparations as well as repurposing, with a special focus on natural supplements and products, clinical and pre-clinical reports.

This collection is inherently interdisciplinary because health problems involve not only medicine and medicinal chemistry, but in the modern holistic conception, essential contributions come from biological, biotechnological, and pharmaceutical research as well as from physics and chemistry.

Contributions to this Research Topic ideally deal, although not exclusively, with:

- Modeling molecules and biomolecules showing antioxidant activity.

- Antioxidant enzymes, mimics, and drugs with therapeutic potential in CNS diseases.

- Endogenous, synthetic, or natural antioxidant compounds with therapeutic potential in CNS diseases.


Keywords: oxidative stress, drug delivery systems for antioxidants, antioxidant molecules, CNS diseases, modeling


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
28 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
28 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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