Research Topic

The role of polyphenols and nanopolyphenols in the management of oxidative stress and metabolic syndromes: Mechanisms and Therapies

About this Research Topic

Polyphenols, of natural origin, are the potential antioxidants in the human diet. There are thousands of natural polyphenols in the plant kingdom. Oxidative stress (a pro-oxidant/antioxidant imbalance) has a significant role in the development of various diseases such as diabetes, obesity, metabolic syndromes, chronic obstructive pulmonary disease, chronic kidney disease, arthritis, dementia, cancer, and atherosclerosis. The oxidative stress by various mechanisms is related to metabolic syndrome. This disorder is a cluster of health problems that associated with insulin resistance, obesity, impaired glucose tolerance, dyslipidaemia, and ‎hypertension.

Polyphenols have attained considerable interest because of their potential pharmacotherapeutic effects, including anti-diabetic, antihypertensive, anti-obesity, anti-inflammatory, and anti-hyperlipidaemic. Polyphenols by increasing the insulin action and β-cell regeneration can alleviate the harmful effects of diabetes. Polyphenols are edible components of various food sources like grapes, wine, vegetables, green tea, coffee, and red fruits. Some of these agents are suggested as nutraceutical medicinal drugs. The biological activity and pharmaceutical application of polyphenols is limited by their low solubility, instability at low pH, and rapid elimination. Nano formulations of polyphenols improve their bioavailability, biodistribution, physicochemical properties, specificity, and efficacy.

I would like to invite scientists to submit a paper focusing on “The role of polyphenols and nanopolyphenols in the management of oxidative stress and metabolic syndromes: Mechanisms and Therapies”. Molecular and mechanism of action studies are welcome as well as experiments both on animals and humans. Novel scientific findings on standard prevention and treatments will be considered. We encourage comprehensive reviews, meta-analysis, original articles, and Letter to the Editor.

Potential topics include but are not limited to the following:
• Polyphenols and nanopolyphenols and oxidative stress
• Polyphenols and nanopolyphenols and diabetes
• Polyphenols and nanopolyphenols and metabolic syndromes
• Polyphenols and nanopolyphenols and insulin resistance

Important note: All manuscripts submitted through the section Experimental Pharmacology and Drug Discovery will need to follow the Guidelines for the conception/peer-review of submissions of this Section. Studies carried out with crude extracts/multiherbal preparations/multiple compounds or Original Research based solely on in silico techniques will not be considered for review. Clinical reports and/or meta-analysis will also not be considered, because our section does not include clinical pharmacology.


Keywords: Dietary Polyphenols, Flavonoids, Insulin Resistance, Mechanisms of Action, Bioavailability, Natural Products, Metabolic Syndrome, Oxidative Stress, Obesity, Cardiovascular Disease, Diabetes, Polyphenols, Nanopolyphenols


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Polyphenols, of natural origin, are the potential antioxidants in the human diet. There are thousands of natural polyphenols in the plant kingdom. Oxidative stress (a pro-oxidant/antioxidant imbalance) has a significant role in the development of various diseases such as diabetes, obesity, metabolic syndromes, chronic obstructive pulmonary disease, chronic kidney disease, arthritis, dementia, cancer, and atherosclerosis. The oxidative stress by various mechanisms is related to metabolic syndrome. This disorder is a cluster of health problems that associated with insulin resistance, obesity, impaired glucose tolerance, dyslipidaemia, and ‎hypertension.

Polyphenols have attained considerable interest because of their potential pharmacotherapeutic effects, including anti-diabetic, antihypertensive, anti-obesity, anti-inflammatory, and anti-hyperlipidaemic. Polyphenols by increasing the insulin action and β-cell regeneration can alleviate the harmful effects of diabetes. Polyphenols are edible components of various food sources like grapes, wine, vegetables, green tea, coffee, and red fruits. Some of these agents are suggested as nutraceutical medicinal drugs. The biological activity and pharmaceutical application of polyphenols is limited by their low solubility, instability at low pH, and rapid elimination. Nano formulations of polyphenols improve their bioavailability, biodistribution, physicochemical properties, specificity, and efficacy.

I would like to invite scientists to submit a paper focusing on “The role of polyphenols and nanopolyphenols in the management of oxidative stress and metabolic syndromes: Mechanisms and Therapies”. Molecular and mechanism of action studies are welcome as well as experiments both on animals and humans. Novel scientific findings on standard prevention and treatments will be considered. We encourage comprehensive reviews, meta-analysis, original articles, and Letter to the Editor.

Potential topics include but are not limited to the following:
• Polyphenols and nanopolyphenols and oxidative stress
• Polyphenols and nanopolyphenols and diabetes
• Polyphenols and nanopolyphenols and metabolic syndromes
• Polyphenols and nanopolyphenols and insulin resistance

Important note: All manuscripts submitted through the section Experimental Pharmacology and Drug Discovery will need to follow the Guidelines for the conception/peer-review of submissions of this Section. Studies carried out with crude extracts/multiherbal preparations/multiple compounds or Original Research based solely on in silico techniques will not be considered for review. Clinical reports and/or meta-analysis will also not be considered, because our section does not include clinical pharmacology.


Keywords: Dietary Polyphenols, Flavonoids, Insulin Resistance, Mechanisms of Action, Bioavailability, Natural Products, Metabolic Syndrome, Oxidative Stress, Obesity, Cardiovascular Disease, Diabetes, Polyphenols, Nanopolyphenols


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

22 August 2021 Abstract
20 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

22 August 2021 Abstract
20 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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