About this Research Topic
Transcriptional regulation plays a critical role in mounting an appropriate immune response to pathogens. The control of transcript expression in the many different cells of the immune system is highly regulated. Strict control is necessary to ensure a well-coordinated response is mounted that both stops the invading pathogen while minimizing damage to the host. Dysregulation of the transcriptional response, due to natural variation in the immune system or some pathogenic mechanism, can lead to severe illness in infectious disease.
A mechanistic understanding of the sequence of events fundamental to the regulation of transcription during the host immune response is necessary to identify treatments and methods of prevention in severe disease. Transcription can be regulated on multiple levels such as genetic variation, changes to chromatin topology, DNA methylation and histone modifications. These can all work in tandem to govern access to promoter regions on DNA for regulatory molecules that directly bind DNA and its associated proteins. Linking transcriptomics to epigenetics and genomics can uncover the regulatory factors and processes that maintain an effective host:pathogen response.
This Research Topic aims to investigate transcriptional events causal to disease progression in infectious disease, with a focus on the underlying genetics. The topic will include on-going questions such as how specific genetic variants modulate transcriptional events during the host immune response and how both pathogen and host transcriptional mechanisms coordinate to benefit the survival of the host or the replication of the pathogen.
We welcome the submission of Original Research, Review articles and Short Communications that include, but are not limited to, the following topics:
1. Genetic variation underlying changes to transcriptional regulation
2. Transcriptional regulation in innate immunity
3. Transcriptional regulation in adaptive immunity
4. Development of models to understand transcriptional mechanisms underlying disease progression in pathogen infection
5. Evolutionary and comparative perspectives of transcriptional mechanisms underlying the host response to infection.
This Research Topic is not limited to lab-based experiments and we would like to include computational analyses. Further, we will not limit the topic to any specific pathogen or host species.
The Editors acknowledge Dr. Thomas Hall (University College Dublin), who contributed to the preparation of the Research Topic proposal.
Keywords: transcriptional regulation, immune response, pathogen, host, infectious disease, genetic variation, innate immunity, adaptive immunity, pathogen infection
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.