About this Research Topic
Although neurodegenerative disorders are becoming a significant public health concern, early diagnosis and treatment for such diseases are still limited. These diseases often share similar neuropathic symptoms and underlying pathological mechanisms. So, it is important to understand the role of aging-related proteins in neurodegenerative diseases, which provide new clues for therapeutical treatments of these diseases.
Protein modifications play important roles in protein transportation, function and degradation. In cells, it is crucial to keep the balance of protein modifications, such as ubiquitination, phosphorylation, methylation, acetylation, etc. In the past decades, the role of protein ubiquitination in neurodegenerative diseases has been widely studied. The dysregulation of protein ubiquitination could lead to abnormal protein accumulation in neurons and cause neurodegenerative diseases. However, many other mechanisms of protein modification in aging and neurodegeneration are still unrevealed.
This Research Topic aims to explore and highlight recent studies on the regulatory roles of protein modification, including ubiquitination, phosphorylation, methylation, acetylation, in age-related neurodegenerative diseases, such as Alzheimer's Disease (AD) and Parkinson Disease (PD). Moreover, this Research Topic would also like to focus on the common pathological protein modification pathway between age-related neurodegenerative diseases to provide potential therapeutical approaches.
We welcome all original research article and reviews that related to the following topic:
- Identifying the molecular mechanism of protein modification in AD and PD
- Studying the regulatory roles of protein modification in different neuronal cell types in AD and PD (Neurons, microglia, astrocytes, oligodendrocytes, etc)
- Investigating the association between protein modification and age-related neurodegenerative diseases in clinical research.
- Exploring the intervention of the protein modification-related molecular targets in AD and PD
- Studying the roles of protein modification in the cognitive impairment of age-related neurodegenerative disease are equally welcome (the single-center genetic observation are not included).
Keywords: Protein Modification, Neurodegenerative Diseases, Alzheimer's Disease, Parkinson Disease, Aging
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