About this Research Topic
Systems immunology covers research areas that employ a holistic strategy to understand how the immune system components comprehensively interact in healthy and disease conditions such as development, growth, differentiation, aging, cancer, autoimmune, auto-inflammatory, infectious diseases. Advances in high throughput technologies (e.g., RNA-Seq, ATAC-Seq, Single-Cell RNA-Seq, and mass spectrometry) have enabled researchers to explore the dynamics and orchestration of thousands of molecules such as transcripts, proteins, metabolites, cytokines, chemokines, and their receptors under steady or perturbation states. By these means, systems immunology approaches have revolutionized biomedical research, identifying new relationships in signaling pathways, crosstalk between receptors, and cell interactions involved in the immune response.
Infectious diseases are disorders caused by organisms including bacteria, viruses, and parasites. The cells of the innate immune system can recognize molecules present on the surface of these pathogens and react to signaling molecules produced during an infection to fight the invasion. This immune response to the pathogen causes inflammation. Meanwhile, autoinflammatory disorders result from issues with the innate immune system, which usually fights off these pathogens. This results in the innate immune cells attacking the body, leading to recurrent inflammatory episodes.
Translationally, systems immunology by employing transcriptomic and proteomic analysis has, for instance, improved the treatment and diagnosis of infectious diseases and autoinflammatory disorders. This Research Topic aims to collect articles focusing on transcriptome and proteome analyses that comprehensively characterize the distinct and common inflammatory responses present in infectious diseases and autoinflammatory disorders. We will also be interested in analyses that identify novel distinct immune biomarkers profiles present in infectious diseases and autoinflammatory disorders. By furthering our understanding of the distinctions in the inflammatory pathogenesis and immune biomarkers present in individuals with these disorders, this should assist in improving the diagnosis and subsequently the treatment of autoinflammatory disorders and infectious diseases.
We encourage the submission of Original Research, Systematic Review, and Review articles looking into the use of transcriptome and proteome analyses in:
1. Novel inflammatory biomarkers in infectious diseases and autoinflammatory disorders, and the distinctions between biomarkers seen in infectious diseases and autoinflammatory disorders.
2. Novel inflammatory mechanisms in infectious diseases and autoinflammatory disorders, and distinctions in the inflammatory pathways.
3. Distinctions in immune biomarkers and inflammatory pathways in guiding the treatment and diagnosis of autoinflammatory disorders and infectious diseases.
Keywords: Systems Immunology, immunological interactions, infections, Inflammation, transcriptome, proteome
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.