About this Research Topic
Obstetrical complications, including gestational diabetes mellitus, preeclampsia, fetal growth restriction, preterm labour, preterm prelabour rupture of membranes and fetal demise are all the clinical endpoint of several underlying mechanisms (Infection, inflammation, thrombosis, endocrine disorders, immunologic rejection, genetic and environmental). These conditions may be associated, in different moments and different ways, with placental structural and functional alterations. But what is the placenta? The placenta is the maternal/fetal interface, essential for successful pregnancy development, and is a highly fascinating engineering production of nature. The placenta undergoes profound changes from first to third trimester, and its impact on pregnancy outcome as well as on life-long health of the offspring is becoming more and more evident.
Modern Obstetrics are running towards prevention of complications. Three levels of prevention can be programmed, represented by primary, secondary, or tertiary prevention of pregnancy complications. The best strategies are those allowing to achieve the first two levels of prevention. Therefore, it is crucial to design studies addressing the question of how the placenta changes in the presence of pathologic conditions of pregnancy, in order to understand the pathophysiology of placental disorders associated with pregnancy complications, and prevent their negative maternal and fetal/neonatal outcomes. Several authors have tried to address this task, although more studies need to be performed.
The present research topic aims to convey retrospective and prospective studies, as well as systematic reviews of the literature, assessing potential association of placental alterations and changes with obstetric complications. In addition, studies analyzing the pathophysiology and the molecular basis of the mechanisms leading to adverse outcomes of pregnancy would be of great interest to the topic.
Keywords: Placenta, Great Obstetrical Syndromes, Preterm labor, PROM, Chorioamnionitis, Gestational diabetes mellitus, IUGR, Fetal demise
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