About this Research Topic
The cell membrane is a fluidic lipid bilayer constituted by different domains that serve as platforms for regulating cellular signaling. Many receptors, ion channels, and intracellular proteins interacting with the plasma membrane microdomains (PMMDs) are critical for downstream effects in physiological and pathological conditions, with the latter especially relevant in neurodegenerative diseases (NDDs).
Cell homeostasis relies on changes in PMMDs, eliciting interactions with misfolded proteins, cell-to-cell vesicle transfer, and receptors and channel activation. Cumulative changes in any of them may trigger intracellular events leading to NDDs. Cell culture under conditions simulating different aspects of NDDs have consistently identified signaling pathways associated with a phenotype consistent with NDDs.
The goal of this collection is to collate cutting-edge science on changes in PMMD composition and their downstream pathways that may lead to the onset, or add to the morbidity, of NDDs by utilizing cell models. We are interested in in vitro models, including primary cell cultures, established transformed cell lines and iPSCs that mimic different aspects of NDD pathophysiology. We also encourage submissions that report novel findings on species differences in cell culture models of NDDs.
The aim of the current Research Topic is to cover novel and innovative research in the area of PMMD biology and its downstream effects in NDDs by utilizing cell culture models. Areas to be covered in this Research Topic may include, but are not limited to:
- PMMD composition (proteins and lipids) and clusters
- PMMD interactions with ion channels, receptors and misfolded proteins
- Post-translational modifications, trafficking and vesicles associated with PMMDs
- Downstream effects of these interactions, such as: signaling pathway activation, secondary messenger signaling and regulation of gene expression
Keywords: plasma membrane, neurodegenerative diseases, cell culture models, signaling pathways, plasma membrane microdomains, neurodegenerative mechanisms, lipid compositions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.