About this Research Topic
Alzheimer’s disease and other forms of dementia or neurodegeneration are the 7th most common cause of death globally. The majority of the cases correlate with age progression manifesting amassed pathology with increasing age. Some of the common characteristics along others, include the fact that they are age-dependent and require a significant amount of time to develop and exhibit symptoms and their sporadic nature, with causative agents being largely unknown. Moreover, therapeutic intervention is mainly limited to render symptomatic relief. Humans are exposed to a plethora of dietary and environmental toxicants throughout their lifespan, which could be potential triggers to lead the onset or progression of these disorders. Considering that the nature of Alzheimer’s and Parkinson’s disease is mostly sporadic, the need to study toxicants as contributing factors in the disease pathology is of paramount importance. In contrast to environmental toxicants, dietary toxicants are relatively understudied and warrant more attention and studies to be undertaken.
This Research Topic will invite Original Research and Review articles, which focus on different aspects of chemical-induced neurotoxicity, chemical-induced toxic protein accumulation leading to neuro-behavioral or morphological alterations in neurons, biotransformation of neurotoxic chemicals and biomarkers when it comes the effects and exposure of these neurotoxic chemicals in humans as well as in laboratory animals. Research utilizing cell lines and model organisms will also be included. Given that dietary toxicants are relatively understudied, we would like to encourage amassed research in this area. In addition, we will place emphasis on studies highlighting the use of in-silico methodologies towards the prediction of neurotoxicity/neurotoxicological targets and the discovery of therapeutic agents. This collection will contribute to a better understanding, specifically of the role of toxicants, their underlying mechanisms, and the use of novel methodologies, particularly in-silico techniques, to guide future studies that can improve human health.
Subtopics to be addressed include but are not limited to:
- Toxicant induced cholinergic cell death/ behavioral alteration.
- Toxicant induced dopaminergic cell loss/ behavioral alteration.
- Impact of toxicants on accumulation/aggregation of amyloid-beta or alpha-synuclein.
- Toxicant induced alteration of toxic protein clearance.
- Effect of toxicants on neurotransmitter level, synthesis, and metabolism.
- Breakthrough in target prediction using in-silico methodologies.
- Synergistic effect of toxicants on disease progression.
- Dietary toxicants as modulators of pathology.
- Biomarkers for investigating the effects and exposure of these neurotoxic chemicals.
- Neurodegenerative disorders with overlapping mechanism or targets.
- Dietary factors such as high fat, AGE as risk factors for neurodegenerative disorders.
Keywords: Alzheimer's disease, Parkinson's disease, neurotoxicity, neurodegeneration, pesticides, toxicants
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.