About this Research Topic
The collateral effects of radiotherapy for head and neck therapy are a great challenge for professionals of oral medicine. They can be acute and lead to interruption of the therapy, increased costs, reduced survival rates, and their complications can be temporary or late. Late effects, such as radiation caries and osteoradionecrosis could be associated with patients that do not receive previous dental evaluation, severely affecting post-treatment quality of life. There is a need to better understand these complications and create new strategies to predict toxicities, as well as prevent and treat these adverse effects. A multidisciplinary approach to the management of these patients is necessary, including oral health care professionals in the team.
Our main goal is to publish the most recent perspective and findings about oral and orofacial complications of cancer therapy. Articles will include important data about the clinical approach to diagnosis and management of these conditions, molecular biomarkers utilized in follow-up, and how this information can help to predict these adverse effects, with impact on treatment and monitoring decisions.
Oral complications and themes that will be considered in this Research Topic include: oral mucositis, dry mouth/hyposalivation, dermatitis, trismus, dysgeusia, dysphagia, candidiasis, radiation caries, medication-related osteonecrosis of the jaw, graft-versus-host-disease, oral oncology today, radiation therapy, oral immune‐related adverse events, complications of targeted therapies, risk prediction and clustering of toxicities, dental clearance protocols, and photobiomodulation therapy.
Studies are not limited to oral cancer, since studies involving oropharyngeal, larynx and other head and neck cancer can also induce oral complications.
High-quality reviews and original research are welcome, involving observational and experimental data of basic and clinical research. The scope includes different areas of interest, such as: epidemiology, pathology, clinical reports, bioinformatics, pharmacology, and molecular biology.
Keywords: Oral Oncology, Oral mucositis, Osteoradionecrosis, Radiation caries, Hyposalivation, Side-effects
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.