Research Topic

Cardiovascular Neuromodulation: Mechanisms & Therapies

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Cardiovascular Neuromodulation: Mechanisms & Therapies

The autonomic nervous system (ANS) plays a central role in the pathogenesis of several cardiovascular diseases such as:

-Hypertension
-Pulmonary hypertension
-Myocardial infarction
-Atrial fibrillation
-Ventricular tachyarrhythmias/fibrillation (VT/VF)
-Heart failure

Cardiovascular diseases (CVDs) are the leading cause of death -globally, taking an estimated 17.9 million lives each year ( 31 % of all deaths worldwide ). Mechanisms implicated in the pathophysiology of CVD include autonomic nervous system (ANS) dysfunction, endothelial dysfunction , vasoconstriction, and systemic inflammation.

Today, several therapeutic options are available to treat heart and cardiovascular patients, mainly medical therapies targeting specific pathways in vascular biology and physiology, centered around vasoconstriction, cell proliferation, sympathetic overactivity, defective renin-angiotensin-aldosterone system and ANS imbalance. Those drugs have improved the quality of life and survival of patients. On the other hand, they do not cure the disease and are associated with side effects like dry cough, flushing, peripheral edema, hyperkalemia, hypotension, and reduction of cardiac output. Despite significant advances, CVDs remain a serious, life-threatening condition and new therapeutic modalities must be pursued.

Neuromodulation therapies, which is one of the upsurging fields of modern medicine, involving a wide range of specialties and a variety of disorders. It is the process of stimulation, inhibition, regulation, or therapeutic alterations of the electrical or/and chemical activities, in the central, peripheral, or autonomic nervous systems that can be directed toward reverse/prevent progression of cardiovascular disease, by using implantable or non-implantable medical devices such as pacemakers, neural stimulators or micro-infusion pumps.

Therapies such as stellate ganglionectomy/cardiac sympathetic denervation (CSD) to prevent life-threatening arrhythmias and renal artery denervation (RAD) to treat resistant hypertension are now being clinically utilized, and other neuraxial approaches show a lot of promise including vagus nerve stimulation (VNS), tragus nerve stimulation, cardiac contractility modulation, baroreceptor activation therapy and spinal cord stimulation, with an optimal combination of pharmacological therapy as a management of heart failure (HF).


Keywords: Heart, cardiovascular, autonomic nervous system, nerve stimulation, arrhythmia


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cardiovascular Neuromodulation: Mechanisms & Therapies

The autonomic nervous system (ANS) plays a central role in the pathogenesis of several cardiovascular diseases such as:

-Hypertension
-Pulmonary hypertension
-Myocardial infarction
-Atrial fibrillation
-Ventricular tachyarrhythmias/fibrillation (VT/VF)
-Heart failure

Cardiovascular diseases (CVDs) are the leading cause of death -globally, taking an estimated 17.9 million lives each year ( 31 % of all deaths worldwide ). Mechanisms implicated in the pathophysiology of CVD include autonomic nervous system (ANS) dysfunction, endothelial dysfunction , vasoconstriction, and systemic inflammation.

Today, several therapeutic options are available to treat heart and cardiovascular patients, mainly medical therapies targeting specific pathways in vascular biology and physiology, centered around vasoconstriction, cell proliferation, sympathetic overactivity, defective renin-angiotensin-aldosterone system and ANS imbalance. Those drugs have improved the quality of life and survival of patients. On the other hand, they do not cure the disease and are associated with side effects like dry cough, flushing, peripheral edema, hyperkalemia, hypotension, and reduction of cardiac output. Despite significant advances, CVDs remain a serious, life-threatening condition and new therapeutic modalities must be pursued.

Neuromodulation therapies, which is one of the upsurging fields of modern medicine, involving a wide range of specialties and a variety of disorders. It is the process of stimulation, inhibition, regulation, or therapeutic alterations of the electrical or/and chemical activities, in the central, peripheral, or autonomic nervous systems that can be directed toward reverse/prevent progression of cardiovascular disease, by using implantable or non-implantable medical devices such as pacemakers, neural stimulators or micro-infusion pumps.

Therapies such as stellate ganglionectomy/cardiac sympathetic denervation (CSD) to prevent life-threatening arrhythmias and renal artery denervation (RAD) to treat resistant hypertension are now being clinically utilized, and other neuraxial approaches show a lot of promise including vagus nerve stimulation (VNS), tragus nerve stimulation, cardiac contractility modulation, baroreceptor activation therapy and spinal cord stimulation, with an optimal combination of pharmacological therapy as a management of heart failure (HF).


Keywords: Heart, cardiovascular, autonomic nervous system, nerve stimulation, arrhythmia


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

29 August 2021 Abstract
27 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

29 August 2021 Abstract
27 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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