Research Topic

Gasotransmitter Signaling in the Cardiovascular System: Physiological Roles, Pathological Implications and Therapeutic Applications

About this Research Topic

Gasotransmitters are gaseous signaling molecules, endogenously produced through specific intracellular enzymatic pathways and extensively involved in several physiological and pathological processes, by both paracrine and autocrine mechanisms. Among these unusual signaling molecules, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) represent the leader and most studied members, even if other endogenously synthesized gases, such as ammonia and sulfur dioxide, are currently under investigation for their potential enrollment in this category.

The epochal interest in endogenous gasotransmitters arose from the discovery of the capital involvement of NO in the regulation of vascular tone. Starting from this pillar, exponential scientific literature has followed, gaining knowledge concerning physiological, pathological and therapeutic implications of these molecules in the cardiovascular system.



One of the most unsolved issue in the cardiovascular research field, especially boosted during the Covid-19 pandemic, is represented by the detrimental progression of endothelial dysfunction toward severe cardiovascular and, more broadly, systemic disorders. In this context, nitric oxide, carbon monoxide, hydrogen sulfide, and their related pathways, could represent key elements of protective strategies planned to counteract cardiovascular diseases, such as hypertension, atherosclerosis, hypercoagulation and diabetic vascular complications.



Deeper investigations on the molecular mechanisms belonging to gasotransmitter-activated machineries could thus shed light to novel therapeutic approach aimed at preserving and restoring endothelial health.


Keywords: Nitric Oxide, Hydrogen Sulfide, Carbon Monoxide, endothelial cells, cardiomyocytes, vascular smooth muscle, vascular tone, endothelial dysfunction, angiogenesis, vascular remodelling, ischemia-reperfusion injury, cardiac contractility, ion channels, vasculogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Gasotransmitters are gaseous signaling molecules, endogenously produced through specific intracellular enzymatic pathways and extensively involved in several physiological and pathological processes, by both paracrine and autocrine mechanisms. Among these unusual signaling molecules, nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) represent the leader and most studied members, even if other endogenously synthesized gases, such as ammonia and sulfur dioxide, are currently under investigation for their potential enrollment in this category.

The epochal interest in endogenous gasotransmitters arose from the discovery of the capital involvement of NO in the regulation of vascular tone. Starting from this pillar, exponential scientific literature has followed, gaining knowledge concerning physiological, pathological and therapeutic implications of these molecules in the cardiovascular system.



One of the most unsolved issue in the cardiovascular research field, especially boosted during the Covid-19 pandemic, is represented by the detrimental progression of endothelial dysfunction toward severe cardiovascular and, more broadly, systemic disorders. In this context, nitric oxide, carbon monoxide, hydrogen sulfide, and their related pathways, could represent key elements of protective strategies planned to counteract cardiovascular diseases, such as hypertension, atherosclerosis, hypercoagulation and diabetic vascular complications.



Deeper investigations on the molecular mechanisms belonging to gasotransmitter-activated machineries could thus shed light to novel therapeutic approach aimed at preserving and restoring endothelial health.


Keywords: Nitric Oxide, Hydrogen Sulfide, Carbon Monoxide, endothelial cells, cardiomyocytes, vascular smooth muscle, vascular tone, endothelial dysfunction, angiogenesis, vascular remodelling, ischemia-reperfusion injury, cardiac contractility, ion channels, vasculogenesis


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

10 September 2021 Abstract
31 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

10 September 2021 Abstract
31 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..