Research Topic

Long non-coding RNAs, Steroid Hormones, and Cancer

About this Research Topic

Steroid hormones participate in the regulation of fundamental processes in cancer cells through different mechanisms, including the activation of intracellular receptors that act as ligand induced-transcription factors that modify gene expression. The genomic effects of steroid hormones can be regulated by epigenetic events such as those mediated by non-coding RNAs, a group of non-protein coding transcripts of different nucleotides number that regulate the expression of a plethora of genes. Long non-coding RNAs (lncRNAs) are formed by more than 200 nucleotides that regulate crucial processes involved in cancer progression such as metabolism, proliferation, cell death, and metastasis, through the interaction with DNA, RNA, and proteins. It has been recently reported that steroid hormone effects could be mediated by lncRNAs. Revealing the role of these epigenetic regulators in steroid hormone actions in cancer pathophysiology leads us to the understanding of malignancies, and opens a promising area in the diagnosis, prognosis, and treatment of cancer.

In this topic, we will collect recent and relevant advances in the interaction between steroid hormones and lncRNAs and their impact on several types of cancer.
The Topic Editors welcome the submission of basic and clinical original research articles and reviews.


Keywords: Steroids, sex hormones, lncRNAs, epigenetic regulation, tumors, cancer progression


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Steroid hormones participate in the regulation of fundamental processes in cancer cells through different mechanisms, including the activation of intracellular receptors that act as ligand induced-transcription factors that modify gene expression. The genomic effects of steroid hormones can be regulated by epigenetic events such as those mediated by non-coding RNAs, a group of non-protein coding transcripts of different nucleotides number that regulate the expression of a plethora of genes. Long non-coding RNAs (lncRNAs) are formed by more than 200 nucleotides that regulate crucial processes involved in cancer progression such as metabolism, proliferation, cell death, and metastasis, through the interaction with DNA, RNA, and proteins. It has been recently reported that steroid hormone effects could be mediated by lncRNAs. Revealing the role of these epigenetic regulators in steroid hormone actions in cancer pathophysiology leads us to the understanding of malignancies, and opens a promising area in the diagnosis, prognosis, and treatment of cancer.

In this topic, we will collect recent and relevant advances in the interaction between steroid hormones and lncRNAs and their impact on several types of cancer.
The Topic Editors welcome the submission of basic and clinical original research articles and reviews.


Keywords: Steroids, sex hormones, lncRNAs, epigenetic regulation, tumors, cancer progression


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
28 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
28 February 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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