Research Topic

Considering Plant Metabolites and Their Synthetic Derivatives as Candidates for the Development of Drugs Directed Against Multidrug Resistant (MDR) Tumors.

About this Research Topic

Even though pharmacological agents currently used in oncology play a decisive role in the treatment of cancer, the development of multidrug resistance (MDR) and the consequent failures in chemotherapy highlights the dire need to discover new effective agents. One of the main mechanism encountered in MDR, is the overexpression of efflux pumps, in particular of the transporters belonging to the ATP binding cassette (ABC) family.

Notably, plants have been an endless and vital source of compounds with great structural diversity showing various possible modes of action against MDR cancer cells. The enormous potential that lies in plants provide us with new and active chemical entities that can be used by themselves or as scaffolds for the synthesis of derivatives. These facts, serve as a powerful motivation that moves scientists across the globe to continue searching for their therapeutic potential. These structures will enrich natural product libraries to be used for the discovery of lead compounds and the development of drug candidates for a successful chemotherapy against different resistant phenotypes.

This Research Topic intends to display and discuss cutting-edge research illustrating the potential of plant-derived entities and their synthetic derivatives against MDR tumors. We want to bring together and encourage organic chemists, pharmacognocists, pharmacologists, toxicologists, biologists, artificial intelligence experts, computer-aided drug design scientists and clinicians to join forces and collaborate as a multidisciplinary team to tackle this clinical problem. We encourage authors to place a focus on the anti-cancer activity of such plant-derived metabolites and their synthetic agents, their underlying mechanism of action and also on the rational design and synthesis of relevant derivatives to be considered. Ultimately, this can pave the way to improve the outcome and achieve cures in as many patients with cancer as possible.

This article collection will provide extensive and applied knowledge and aim to stimulate interest to find new avenues to develop potential therapeutic agents against multidrug resistance (MDR) tumors.

This Topic will welcome submissions of Original Research, Systematic Reviews, Reviews, Mini Reviews, Perspectives or Opinion dealing with, but not limited to the following themes:

● Identification of compounds obtained from plants and/or their synthetic analogues with proven inhibitory activity against MDR tumor cells.

● In vivo models developed to test plant-derived compounds and synthetic analogues for their inhibitory activity against MDR tumor cells.

● Underlying mechanisms of action behind plant-derived compounds and their synthetic analogues as they act against cancer cells with observed MDR phenotypes.

● Computer-Aided Drug Design (CADD) as virtual tool to be used for screening and prediction of bioactive compounds against MDR tumor cells.

● Structure activity relationship studies (SARS) dealing with synthetic derivatives of natural products that are shown to be active against MDR phenotypes.

Important note: All manuscripts submitted to this collection will need to follow the Guidelines for the conception/peer-review of submissions of the Experimental Pharmacology and Drug Discovery Section. Studies carried out with crude extracts/multiherbal preparations or Original Research based solely on in silico techniques will not be considered for review.


Keywords: Plant-derived compounds, synthetic derivatives, multidrug resistant (MDR) tumors, ABC transporters, cancer therapy, phytochemicals


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Even though pharmacological agents currently used in oncology play a decisive role in the treatment of cancer, the development of multidrug resistance (MDR) and the consequent failures in chemotherapy highlights the dire need to discover new effective agents. One of the main mechanism encountered in MDR, is the overexpression of efflux pumps, in particular of the transporters belonging to the ATP binding cassette (ABC) family.

Notably, plants have been an endless and vital source of compounds with great structural diversity showing various possible modes of action against MDR cancer cells. The enormous potential that lies in plants provide us with new and active chemical entities that can be used by themselves or as scaffolds for the synthesis of derivatives. These facts, serve as a powerful motivation that moves scientists across the globe to continue searching for their therapeutic potential. These structures will enrich natural product libraries to be used for the discovery of lead compounds and the development of drug candidates for a successful chemotherapy against different resistant phenotypes.

This Research Topic intends to display and discuss cutting-edge research illustrating the potential of plant-derived entities and their synthetic derivatives against MDR tumors. We want to bring together and encourage organic chemists, pharmacognocists, pharmacologists, toxicologists, biologists, artificial intelligence experts, computer-aided drug design scientists and clinicians to join forces and collaborate as a multidisciplinary team to tackle this clinical problem. We encourage authors to place a focus on the anti-cancer activity of such plant-derived metabolites and their synthetic agents, their underlying mechanism of action and also on the rational design and synthesis of relevant derivatives to be considered. Ultimately, this can pave the way to improve the outcome and achieve cures in as many patients with cancer as possible.

This article collection will provide extensive and applied knowledge and aim to stimulate interest to find new avenues to develop potential therapeutic agents against multidrug resistance (MDR) tumors.

This Topic will welcome submissions of Original Research, Systematic Reviews, Reviews, Mini Reviews, Perspectives or Opinion dealing with, but not limited to the following themes:

● Identification of compounds obtained from plants and/or their synthetic analogues with proven inhibitory activity against MDR tumor cells.

● In vivo models developed to test plant-derived compounds and synthetic analogues for their inhibitory activity against MDR tumor cells.

● Underlying mechanisms of action behind plant-derived compounds and their synthetic analogues as they act against cancer cells with observed MDR phenotypes.

● Computer-Aided Drug Design (CADD) as virtual tool to be used for screening and prediction of bioactive compounds against MDR tumor cells.

● Structure activity relationship studies (SARS) dealing with synthetic derivatives of natural products that are shown to be active against MDR phenotypes.

Important note: All manuscripts submitted to this collection will need to follow the Guidelines for the conception/peer-review of submissions of the Experimental Pharmacology and Drug Discovery Section. Studies carried out with crude extracts/multiherbal preparations or Original Research based solely on in silico techniques will not be considered for review.


Keywords: Plant-derived compounds, synthetic derivatives, multidrug resistant (MDR) tumors, ABC transporters, cancer therapy, phytochemicals


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 November 2021 Abstract
31 July 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 November 2021 Abstract
31 July 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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