About this Research Topic
Diseases of the central nervous system (CNS) account for some of the most challenging pathologies to diagnose and treat. What is more, for many of such pathologies, no known preventive measures could be undertaken. The standards of care for tackling such diseases have often had only a minor effect on improving the patient's quality of life or survival. This calls for an effort to engage in the discovery of fundamentally new agents and approaches to treating this family of diseases. Here, nanotechnologies particularly stand out because of their proven ability to target localized tissue abnormalities, but also detect disease markers with unprecedented sensitivities and at highly localized scales.
The goal of this Research Topic is to gather expert opinions and exemplary research studies that describe the advent of new nanomedical technologies for improving the treatment of any challenging conditions affecting the CNS. This special issue equally welcomes contributions describing novel approaches and mechanisms of action governing the delivery of active molecules or carriers across the blood-brain barrier.
Topics of interest include nanotechnologies for the targeting of tumors residing in the brain parenchyma, implantable neural devices utilizing nanotechnologies, methods involving the transient permeation of the blood-brain barrier assisting the passage of the nanoparticles into the brain tissues, magnetically guided therapies, receptor-targeting transcytotic drug delivery vehicles for crossing the blood-brain barrier, therapies preventing or reversing the aggregation of amyloid fibers in Alzheimer's disease, nanotechnologies for diagnostics or treatment of viral, bacterial or parasitic infections of the CNS, and others. Research articles, reviews, and shorter commentaries on any aspect of the progress in these new technologies are invited.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.