About this Research Topic
DNA, peptides, and proteins are functional materials in living organisms that support essential biological processes. Consequently, chemical modification of biomacromolecules has emerged as a contemporary approach to expand Nature’s toolbox to produce bioconjugates with new properties. In particular, bioconjugates have emerged as important therapeutic materials, and as drug delivery systems. For example, aptamer-, peptide-, and antibody-drug, as well as protein-polymer conjugates have emerged as eminent candidates for targeted drug delivery. Through chemical design, the limitations of chemistry and biology are overcome to give rise to a new generation of functional bioconjugates which outperform their individual components.
Bioconjugates offer the advantage that their functions, stability, and controlled release can be tailored according to synthetic design. Coupled with ease of characterization, they are becoming increasingly important for drug delivery applications, both in academic research and the pharmaceutical industry. This Research Topic will cover recent advances in chemical strategies to design bioconjugates with potential for drug delivery.
Manuscripts reporting Original Research, Perspectives, Reviews, and Mini-reviews, are welcome. Themes may include, but are not limited to:
• Bioconjugation chemistry methods that allow the customization of peptide/oligonucleotide/protein for drug delivery
• Bioconjugates designed for (targeted) drug delivery
• New linker chemistry for smart bioconjugates that that allow for controlled release
• Multifunctional bioconjugates with the potential for drug delivery
Dr. Vishal Rai is the scientific founder and Director of Plabeltech Private Limited. He is also a co-inventor of five patents that are licensed to Plabeltech. Prof. Hongyan Sun is the co-inventor of a patent in the field of anticancer drug design. The other Topic Editors declare no competing interests.
Keywords: smart bioconjugates, drug delivery, nanocarriers, multifunctional bioconjugates
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