About this Research Topic
In recent years, research has focused heavily on the development of nanosystems with biological activities applicable to translational medicine, pharmacology and diagnostics. Nanodevices aimed at interacting with cells and tissues are crucial in order to carrying out very specific tasks. There are many areas of application which include: drug discovery, organ-on-a-chip, targeted therapies, drug delivery systems (core-shell particles, hydro and ferrogel and other colloidal systems), disease model system. Among them, nanostructures functionalized with biomolecules display interesting properties and increased bioavailability. Peptide-based nanodrugs, including the use of peptidomimetics and peptide nucleic acids (PNA) for cancer cell targeting, engineered glycans-based theranostic systems, are just some promising examples with growing scientific implications.
A strong potential for the rapid development of biomedical applications based on nanotechnology is represented by nanomaterials and their versatile properties. A major challenge in tissue engineering and precision medicine, is recreating a dynamic 3-D microenvironment in terms of its biological, chemical and physical/mechanical cues, to accurately model the initiation and progression of disease in the laboratory. Despite major effort in designing and fabricating nanomaterials and nanodevices with the desired chemical, physical and biological properties, there is still a gap to fill. Specifically, designing materials with sufficient complexity to replicate the native cells and tissues environment; conferring a high degree of compatibility towards cells and biomolecules; providing the necessary multivalent transduction tools in order to investigating bio-events at the molecular level.
The purpose of this Research Topic is a collection of articles in the subfields of nanofabrication, functional nanoparticles and nanomaterials, molecular engineering and bionanotechnology written by experts with the goal of bringing innovations in a field of fundamental importance for scientific research.
This Research Topic aims to collect original research, review, and a range of other article types with a focus on the nanodevices, nanomaterial and nanocomposites and their applications in precision medicine, tissue engineering.
We invite authors to submit manuscripts which address, but are not limited to, the following themes:
• 3D electroactive scaffold for diagnostics
• Hydrogel based glycomaterials
• Host-pathogen interaction mechanisms
• Electronic nanodevices
• Nanodevices functionalized with biomolecules or biopolymers, for recognition, detection and inhibition of biological targets
• The use of nanomaterials to accurately model disease progression
Keywords: Nanomaterials, Theranostic, Diagnostic, Nanodevices, Models, Mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.