About this Research Topic
Drinking-water distribution systems (DWDSs) and drinking water (DW) quality play a crucial role in the health and in performance of livestock. DW represents the most common way for the administration of antimicrobial drugs (AMD), being cost-effective and allowing a safe administration and a rapid distribution to a large number of animals. However, the administration of antimicrobials via DW is not without disadvantages. In fact, DWDSs and DW can be contaminated with chemicals and microbiological components, that may influence the stability and viability of some antimicrobials and lead as a consequence, to biofilm formation inside the pipeline. This inevitably contributes to the emergence and dissemination of antimicrobial resistance (AMR). Biofilms represent hotspots for antimicrobial resistance gene (ARGs) transfers and, despite they do not necessarily include pathogens, they can provide an ideal substrate for their growth, contribute to the development of pathogenic resistant bacteria, and create a potential risk for both animal and human health.
The implementation of high-throughput technologies, such as the ones applying metagenomics and transcriptomics, will allow a knowledge advance especially about: i.) the biofilm formation within conventional farm water pipelines, ii.) the survival strategies of biofilms under the pressure of AMDs, and iii.) the emergence and spread of AMR in biofilms. Indeed, a better understanding of these phenomena is crucial to ensure not only the efficacy of AMD treatment via DW but also to tackle the dissemination of AMR in the environment and in the food chain, posing a threat to human health.
In this Research Topic, we welcome research articles, notes, and review articles focusing on but not restricted to:
1. Biofilm formation in farm DWDSs
2. Prevalence and diversity of ARGs in biofilm
3. Influence of AMDs administration on biofilm microbiome and resistome
4. Genetic mechanism of biofilm response to AMDs
This Special Issue is supported by COST Action CA18217 – European Network for Optimization of Veterinary Antimicrobial Treatment.
Keywords: Biofilm, Antimicrobial Resistance, Resistome, Microbiome, Transcriptome
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