About this Research Topic
Vasculitides that affect children are a challenging and rare group of disorders that may involve any system and organ and may cause significant morbidity and mortality. Vasculitis in childhood could also be developed secondary to a wide range of disorders including immune-mediated conditions such as autoimmune and autoinflammatory diseases, immunodeficiencies, as well as malignancies and infections. In CHCC2012 secondary vasculitis was suggested to cover those associated with systemic diseases and vasculitides due to probable causes. This latter section now includes vasculitides associated with monogenic defects such as DADA2. In CHCC2012 this section also covered vasculitis associated with certain infections such as hepatitis or syphilis but we now have a new infection, COVID-19, that may be a causative factor as well. However we lack data to clarify pathogenetic pathways in this association.
Autoinflammatory diseases (AID) may also be associated with vasculitis. AID are characterized by recurrent episodes of systemic inflammation due to exaggerated activation of the innate immune system. These episodes usually occur with fever accompanied by other systemic manifestations such as rash, arthritis, serositis, lymphadenopathy, and also vasculitis.
COVID-19 manifests in children in different systemic involvements beyond the lung involvement, unlike adult patients. Vasculitis or vasculopathy is one of the most striking features of COVID-19 infection. Coronary artery vasculitis or Kawasaki-like disease typically occurs as part of hyper inflammation, named multisystem inflammatory syndrome (MIS, or MIS-C). Besides there are plenty of skin features resembling vasculitic rashes associated with COVID-19.
A better understanding of the underlying mechanisms is needed to enlighten the pathogenesis of secondary vasculitis including those associated with autoinflammatory diseases and COVID-19 infection. This research topic aims to shed light on vasculitis in autoinflammatory diseases and COVID-19 infection.
This special research topic will incorporate new data in the pathogenesis, clinical aspects, diagnostic and treatment approaches in secondary vasculitis including those associated with specific diseases or drugs or are due to single gene defects or those due to infections, including COVID-19. Submissions are welcome for the following article types: original research, reviews, mini-reviews, systematic reviews, or case reports.
Keywords: childhood vasculitis, secondary vasculitis, autoinflammatory diseases, COVID-19
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