About this Research Topic
The liver has been recognized for its essential metabolic functions, contributing to the removal of waste products from the bloodstream, homeostasis of glucose, and metabolic functions, amongst others. Therefore, any internal or external disturbance in the liver function could originate serious health consequences, frequently triggered by various toxics, such as alcohol, drugs, viruses as well as cancer development.
Liver diseases (LD), represent a worldwide major health problem. Indeed, several LD such as fatty liver disease, cirrhosis, and hepatocellular carcinoma, have been associated with the development of cardiovascular diseases, which negatively affect the quality of life of patients.
Given the importance and incidence, a few options for treating LD have been adopted in clinics, such as liver surgical and pharmacological therapy which is the most used. Liver transplantation and liver resection, common surgical procedures for treating some LD, often are the only life-saving treatment for advanced LD, nevertheless, the global impact of ischemia-reperfusion, liver failure, and cardiovascular complications after surgery have emerged as the main causes of death. Similarly, the medication used to treat LD or administered after or before liver surgery (perioperative drugs) could be associated with cardiovascular disturbances. In this sense, it becomes important to better understand the Liver-Cardiovascular System axis in disease, surgery, and/or pharmacological treatments.
The objective of this Research Topic is to welcome manuscripts (original papers, reviews) in order to better understand the relation between LD and liver surgeries with cardiovascular complications, focusing on the endocrinological aspects of such relationships; link the pharmacological treatments used in LD with cardiovascular alterations, and evaluate the effects of medication used in perioperative liver surgeries on cardiovascular disturbance. Hence, the scope of the manuscripts for this Research Topic is, but not limited to, the following:
a) Association of liver diseases with cardiovascular disturbances at physiological and/or biochemical levels
b) Cardiovascular disorders associated with surgical procedures performed in the liver, such as liver transplantation and hepatic resection
c) Pharmacological treatments used in LD and their effect on cardiovascular health
d) Cardiovascular toxicity of drugs, approved or in the experimental phase, used to treat liver diseases as well as in perioperative management of liver surgeries
Keywords: Liver Disease, Liver Surgery, Cardiovascular Complications, Pharmacological Treatments
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.