Research Topic

Gene Therapy and Cell Transplantation for Chronic Pain Management

About this Research Topic

Chronic pain may affect over 20% of the population worldwide, arising as a result of injury or disease of varying etiologies. In contrast to injuries or illnesses that are temporary and resolving, chronic pain can persist and recur for years or indefinitely and may escalate over time. The presence of chronic pain can dramatically reduce productivity and quality of life in otherwise healthy individuals, limiting their participation in daily activities including workforce and recreation. As a result, the continuous or recurrent presence of chronic pain is a significant clinical challenge, since traditional pain medications are often infeasible for long-term administration and maintenance of sufficient levels of pain reduction and can be fraught with undesired side effects at off-target sites. Thus, there is a strong imperative to develop effective long-term therapeutics for the alleviation of chronic pain and restoration of quality of life.



The expanding fields of cell transplantation and gene therapies have been explored for a wide variety of CNS treatments with a number reaching clinical trials. Cell transplantation and gene therapies are potentially transformative approaches in chronic pain management, as they can be disease-modifying and/or provide sustained and continually renewable sources of pain-modulating neuroactive substances, thereby reducing or eliminating the need for repeated systemic analgesics administration and their attendant undesirable side effects. In addition, pharmacologic substances that are labile, have short half-lives, and/or do not readily pass the blood-brain barrier can be delivered to restricted CNS sites via transplanted cells or the direct administration of pain-modulatory transgenes.



Emerging strategies showing promise for chronic pain management include intraspinal transplantation of neural stem cells for integration in dorsal horn neurocircuitry, intrathecal and systemic grafting of mesenchymal stem cells for anti-inflammatory or trophic factor provision, and delivery of a variety of therapeutic analgesic and anti-inflammatory agents via direct gene administration, viral vectors, or engineered cell transplants.



The Research Topic aims to update the most recent developments in these areas including both preclinical and clinical research. Original articles, reviews, and perspectives are welcome.


Keywords: gene therapies, cell transplant therapies, chronic pain, pain management


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Chronic pain may affect over 20% of the population worldwide, arising as a result of injury or disease of varying etiologies. In contrast to injuries or illnesses that are temporary and resolving, chronic pain can persist and recur for years or indefinitely and may escalate over time. The presence of chronic pain can dramatically reduce productivity and quality of life in otherwise healthy individuals, limiting their participation in daily activities including workforce and recreation. As a result, the continuous or recurrent presence of chronic pain is a significant clinical challenge, since traditional pain medications are often infeasible for long-term administration and maintenance of sufficient levels of pain reduction and can be fraught with undesired side effects at off-target sites. Thus, there is a strong imperative to develop effective long-term therapeutics for the alleviation of chronic pain and restoration of quality of life.



The expanding fields of cell transplantation and gene therapies have been explored for a wide variety of CNS treatments with a number reaching clinical trials. Cell transplantation and gene therapies are potentially transformative approaches in chronic pain management, as they can be disease-modifying and/or provide sustained and continually renewable sources of pain-modulating neuroactive substances, thereby reducing or eliminating the need for repeated systemic analgesics administration and their attendant undesirable side effects. In addition, pharmacologic substances that are labile, have short half-lives, and/or do not readily pass the blood-brain barrier can be delivered to restricted CNS sites via transplanted cells or the direct administration of pain-modulatory transgenes.



Emerging strategies showing promise for chronic pain management include intraspinal transplantation of neural stem cells for integration in dorsal horn neurocircuitry, intrathecal and systemic grafting of mesenchymal stem cells for anti-inflammatory or trophic factor provision, and delivery of a variety of therapeutic analgesic and anti-inflammatory agents via direct gene administration, viral vectors, or engineered cell transplants.



The Research Topic aims to update the most recent developments in these areas including both preclinical and clinical research. Original articles, reviews, and perspectives are welcome.


Keywords: gene therapies, cell transplant therapies, chronic pain, pain management


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

01 February 2022 Abstract
01 August 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

01 February 2022 Abstract
01 August 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..