Research Topic

Supra-spinal Mechanism of Neuromodulation for Pain Management

About this Research Topic

In the last three decades, neuromodulation therapy has been a promising option for the treatment of chronic pain, especially for those with intractable neuropathic pain syndrome. However, the mechanism of neuromodulation in pain modulation remains unclear. The supra-spinal modulation is known to play an important role in pain processing. Better understanding of the supra-spinal mechanisms underlying the analgesic effect, provided by either central or peripheral neuromodulation, may help with the optimal stimulation strategy and improve the clinical outcome. In this Research Topics, we aim to discuss the potential mechanisms of neuromodulation in supra-spinal pain signal pathway in both clinical application and basic neuroscience research.



The goal of this Research Topics is to collect the papers that aim to reveal the potential mechanisms of neuromodulation in pain management. By doing this, novel insights of neuromodulation will aid in the development of optimal stimulations strategies and the selection of permanent implantation.



We welcome the submission of manuscripts including, but not limited to, the following topics:



 Cortical and sub-cortical changes with neuromodulation for the control of pain, which can be evaluated by imaging techniques like electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI).

 The contribution of diverse stimulation paradigms, such as tonic and burst spinal cord stimulation.

 The relationship between the neural activity in the brain and peripheral nerve stimulation.


Keywords: neuromodulation, supra-spinal mechanism, spinal cord stimulation, EEG, fMRI, neuropathic pain, peripheral nerve stimulation.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

In the last three decades, neuromodulation therapy has been a promising option for the treatment of chronic pain, especially for those with intractable neuropathic pain syndrome. However, the mechanism of neuromodulation in pain modulation remains unclear. The supra-spinal modulation is known to play an important role in pain processing. Better understanding of the supra-spinal mechanisms underlying the analgesic effect, provided by either central or peripheral neuromodulation, may help with the optimal stimulation strategy and improve the clinical outcome. In this Research Topics, we aim to discuss the potential mechanisms of neuromodulation in supra-spinal pain signal pathway in both clinical application and basic neuroscience research.



The goal of this Research Topics is to collect the papers that aim to reveal the potential mechanisms of neuromodulation in pain management. By doing this, novel insights of neuromodulation will aid in the development of optimal stimulations strategies and the selection of permanent implantation.



We welcome the submission of manuscripts including, but not limited to, the following topics:



 Cortical and sub-cortical changes with neuromodulation for the control of pain, which can be evaluated by imaging techniques like electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI).

 The contribution of diverse stimulation paradigms, such as tonic and burst spinal cord stimulation.

 The relationship between the neural activity in the brain and peripheral nerve stimulation.


Keywords: neuromodulation, supra-spinal mechanism, spinal cord stimulation, EEG, fMRI, neuropathic pain, peripheral nerve stimulation.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

17 September 2021 Abstract
15 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

17 September 2021 Abstract
15 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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