Research Topic

Host-microbe interactions and immunometabolism in Tropical Diseases

About this Research Topic

The host and its endogenous flora have been described as a "holobiont', comprising a delicate ecosystem within one individual. Tropical disease pathogenesis involves more than microbe-host competition, often including aberrations in host-microbe symbiosis.

The host immune system acts not as a defending army, but rather maintains organismal homeostasis of the holobiont during the shifting immune landscapes of reproduction and aging. Immune activation and immune tolerance are intimately linked with metabolic flux, such as shifting between glycolysis and oxidative phosphorylation. The host and its microbial flora share energy currencies such as ATP and NADH as well as carbon sources, amino and fatty acids. Situations of immune compromise, including aging and senescence, are associated with increased microbial virulence, although biochemical mechanisms are only partially understood. Metabolic diseases such as diabetes mellitus often carry consequences of increased risk of infectious disease, and infectious diseases often result in metabolic aberrations in the host. Beneficial effects of vaccination vary depending on host gender and age. Host-directed therapies would be of benefit to treat tropical health scourges including tuberculosis, malaria and HIV.

The goal of this research topic is to collate leading research in host-microbe-immune pathways for enhanced understanding of the root causes of tropical disease. The collection will promote translational approaches for identification of novel drug targets and highlight advances in harnessing repurposed drugs to treat or prevent tropical diseases.

Disease pathogenesis emerges from metabolic cross-talk between microbes and immune cells of its host. Elucidation of host-pathogen dialogue should yield novel therapeutic targets for tropical diseases. In this collection, original research, reviews and critical reviews are welcome in the basic and clinical sciences. For further instructions on article types please see journal instructions for authors. Human and veterinary translational studies are particularly encouraged, All submissions will undergo full peer review. Articles will be published on acceptance and will not depend on publication date of other articles in the collection.


Keywords: metabolism, glycolysis, amino acids, therapy, treatment, macrophages, immune, aging, diabetes, NAD, nicotinamide, vaccine, host, micriobe, flora


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The host and its endogenous flora have been described as a "holobiont', comprising a delicate ecosystem within one individual. Tropical disease pathogenesis involves more than microbe-host competition, often including aberrations in host-microbe symbiosis.

The host immune system acts not as a defending army, but rather maintains organismal homeostasis of the holobiont during the shifting immune landscapes of reproduction and aging. Immune activation and immune tolerance are intimately linked with metabolic flux, such as shifting between glycolysis and oxidative phosphorylation. The host and its microbial flora share energy currencies such as ATP and NADH as well as carbon sources, amino and fatty acids. Situations of immune compromise, including aging and senescence, are associated with increased microbial virulence, although biochemical mechanisms are only partially understood. Metabolic diseases such as diabetes mellitus often carry consequences of increased risk of infectious disease, and infectious diseases often result in metabolic aberrations in the host. Beneficial effects of vaccination vary depending on host gender and age. Host-directed therapies would be of benefit to treat tropical health scourges including tuberculosis, malaria and HIV.

The goal of this research topic is to collate leading research in host-microbe-immune pathways for enhanced understanding of the root causes of tropical disease. The collection will promote translational approaches for identification of novel drug targets and highlight advances in harnessing repurposed drugs to treat or prevent tropical diseases.

Disease pathogenesis emerges from metabolic cross-talk between microbes and immune cells of its host. Elucidation of host-pathogen dialogue should yield novel therapeutic targets for tropical diseases. In this collection, original research, reviews and critical reviews are welcome in the basic and clinical sciences. For further instructions on article types please see journal instructions for authors. Human and veterinary translational studies are particularly encouraged, All submissions will undergo full peer review. Articles will be published on acceptance and will not depend on publication date of other articles in the collection.


Keywords: metabolism, glycolysis, amino acids, therapy, treatment, macrophages, immune, aging, diabetes, NAD, nicotinamide, vaccine, host, micriobe, flora


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

17 September 2021 Abstract
15 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

17 September 2021 Abstract
15 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..