About this Research Topic
The host and its endogenous flora have been described as a "holobiont', comprising a delicate ecosystem within one individual. Tropical disease pathogenesis involves more than microbe-host competition, often including aberrations in host-microbe symbiosis.
The host immune system acts not as a defending army, but rather maintains organismal homeostasis of the holobiont during the shifting immune landscapes of reproduction and aging. Immune activation and immune tolerance are intimately linked with metabolic flux, such as shifting between glycolysis and oxidative phosphorylation. The host and its microbial flora share energy currencies such as ATP and NADH as well as carbon sources, amino and fatty acids. Situations of immune compromise, including aging and senescence, are associated with increased microbial virulence, although biochemical mechanisms are only partially understood. Metabolic diseases such as diabetes mellitus often carry consequences of increased risk of infectious disease, and infectious diseases often result in metabolic aberrations in the host. Beneficial effects of vaccination vary depending on host gender and age. Host-directed therapies would be of benefit to treat tropical health scourges including tuberculosis, malaria and HIV.
The goal of this research topic is to collate leading research in host-microbe-immune pathways for enhanced understanding of the root causes of tropical disease. The collection will promote translational approaches for identification of novel drug targets and highlight advances in harnessing repurposed drugs to treat or prevent tropical diseases.
Disease pathogenesis emerges from metabolic cross-talk between microbes and immune cells of its host. Elucidation of host-pathogen dialogue should yield novel therapeutic targets for tropical diseases. In this collection, original research, reviews and critical reviews are welcome in the basic and clinical sciences. For further instructions on article types please see journal instructions for authors. Human and veterinary translational studies are particularly encouraged, All submissions will undergo full peer review. Articles will be published on acceptance and will not depend on publication date of other articles in the collection.
Keywords: metabolism, glycolysis, amino acids, therapy, treatment, macrophages, immune, aging, diabetes, NAD, nicotinamide, vaccine, host, micriobe, flora
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