About this Research Topic
Maternal infection and inflammation during pregnancy can alter the development and maturation of the offspring's immune system, resulting in both short and long-term consequences on the immune fitness of the offspring. For instance, pregravid obesity and gestational diabetes, both of which are associated with heightened maternal inflammation, are associated with an increased risk of developing asthma, wheezing, and atopic dermatitis in offspring. Maternal infection, notably chorioamnionitis, leads to an increased number and severity of viral respiratory illnesses and persistent wheezing in offspring. While the link between maternal infection and inflammation and offspring immune health is clearly documented, we lack an in-depth understanding of the mechanisms underlying these changes. It is also unclear if different maternal inflammatory and infectious conditions and exposures influence offspring immune function using common or disparate mechanisms.
The goal of this Research Topic is to uncover mechanisms connecting maternal infection and/or inflammation during pregnancy to offspring immune function and immune-related health outcomes. We welcome submissions from both clinical and animal model studies that help elucidate how maternal infections and/or inflammation influence offspring immune health over the lifespan. Studies that go beyond basic immune profiling and instead explore more in-depth mechanisms are particularly encouraged.
In this Research Topic we welcome the submission of Original Research (basic studies, clinical studies) and Review articles focused on these or related topics:
• The effects of maternal infection and/or inflammation on offspring immune function
↳ Including but not limited to pre-pregnancy obesity, gestational diabetes, chorioamnionitis, TORCH infections;
• Comparison of different maternal infectious and/or inflammatory conditions on offspring immune function;
• The association between maternal infection and/or inflammation and immune-mediated diseases in offspring, including susceptibility to and severity of secondary bacterial or viral infections;
• Mechanistic insights into maternal infectious and inflammation-related offspring immune effects, including epigenetics and transgenerational effects
↳ Including but not limited to the interaction of microbes or microbial products with innate immune sensors and ligands and how innate sensing of these microbes or microbial products trigger an inflammatory response in the offspring;
Keywords: Maternal health, pregnancy, immune, offspring, maternal inflammation, maternal infection, myeloid cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.