About this Research Topic
Magnetic Resonance Imaging (MRI) has become an essential tool to evaluate patients with neurodegenerative and neuroinflammatory disorders affecting the Central Nervous System (CNS). Conventional MRI techniques are widely used for the diagnosis and evaluation of patients over-time in clinical settings. However, they rely on a qualitative evaluation of contrasts which hinder the standardization among centers. This limitation impedes the gathering of reliable quantitative information about the structural brain changes that are signs of the disease. The lack of a quantitative analysis limits the power of MRI in deciphering the pathophysiology of brain damage and its changes over time, which can have an impact on patients’ outcome.
To overcome these issues, different quantitative MRI (qMRI) techniques were developed and they have generated a lot of interest within the scientific community in the last decade. Indeed, these techniques are now widely used in research settings and will probably be included very soon in routine clinical MRI protocols too.
The aim of this Research Topic is to present high-quality articles in the field of qMRI. In particular, it will focus on the development of innovative and reliable qMRI methods (including but not limited to relaxometry, quantitative susceptibility mapping, and diffusion models), as well as on the application of qMRI protocols in the evaluation of conditions of different etiologies affecting the CNS (ranging from neurodegenerative to neuroinflammatory disorders, as well as neuro-oncology and neuro-vascular diseases).
We welcome articles focusing but not limited to the following topics:
1) Development of innovative qMRI techniques
2) Comparison of different available qMRI methods and algorithms
3) In vivo application of qMRI methods to evaluate damage in diseases affecting the CNS
Keywords: Neuroimaging, Quantitative MRI, Relaxometry, Quantitative Susceptibility Mapping, Diffusion MRI, Perfusion MRI, Magnetic Resonance Spectroscopy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.