About this Research Topic
Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a relapsing chronic inflammatory disease with high incidence. The limited efficacy of current drug therapies places demands for alternative treatments. Epidemiologic evidence demonstrates that a diverse diet enriched in fruits and vegetables positively correlates with reduced risks of IBD, and this effect has been attributed to bioactive components. Dietary bioactive components, for example, flavonoids, linoleic acid, and tryptophan, are subjected to extensive biotransformation by the host’s enzymes, immune cells, and gut microbiota in the gastrointestinal tract. Reciprocally, dietary bioactive components and primarily their metabolites influence intestinal health by regulating the function of immune cells and altering gut microbiota composition. Challenges with dietary therapy for IBD include the difficult nature of identifying the functional bioactive components/metabolites and the lack of understanding of sophisticated mechanistic pathways to explain the impacts of diet on IBD pathogenesis.
The advances in high throughput multi-omics and sequencing provide toolkits for a comprehensive understanding of nutritional gut homeostasis in IBD. This Research Topic encourages articles that explore novel dietary bioactive components or novel metabolites derived from known bioactive components with the goal of influencing IBD. The testing range of dietary bioactive components includes but is not limited to phytochemicals, herbs, vitamins, minerals, polypeptides, and polysaccharides. In addition, this Research Topic welcomes studies focus on the mechanistic actions of dietary bioactive components/metabolites on gut microbiota and immune responses in IBD. For instance, studies focus on how dietary bioactive components/metabolites regulate gut microbiota, impact inflammatory cytokines, influence intestinal mucosal barrier, and monitor immune cells’ function. Dissecting these scientific questions will provide critical and innovative insights into developing dietary preventative interventions and curative treatments for IBD.
This article collection is looking for original research articles and reviews that focus on but are not limited to the following subtopics:
• Identification and characterization of dietary bioactive components or their novel metabolites that influence IBD.
• Regulation of immune responses by dietary bioactive components and/or their metabolites in the context of IBD.
• Alteration of gut microbiota composition by dietary bioactive components or their metabolites.
• The interactions of gut microbiota and immune responses in IBD.
• Articles leveraging high throughput sequencing and multi-omics techniques are encouraged.
The advances in high throughput multi-omics and sequencing provide toolkits for a comprehensive understanding of nutritional gut homeostasis in IBD. This Research Topic encourages articles that explore novel dietary bioactive components or novel metabolites derived from known bioactive components with the goal of influencing IBD. The testing range of dietary bioactive components includes but is not limited to phytochemicals, herbs, vitamins, minerals, polypeptides, and polysaccharides. In addition, this Research Topic welcomes studies focus on the mechanistic actions of dietary bioactive components/metabolites on gut microbiota and immune responses in IBD. For instance, studies focus on how dietary bioactive components/metabolites regulate gut microbiota, impact inflammatory cytokines, influence intestinal mucosal barrier, and monitor immune cells’ function. Dissecting these scientific questions will provide critical and innovative insights into developing dietary preventative interventions and curative treatments for IBD.
This article collection is looking for original research articles and reviews that focus on but are not limited to the following subtopics:
• Identification and characterization of dietary bioactive components or their novel metabolites that influence IBD.
• Regulation of immune responses by dietary bioactive components and/or their metabolites in the context of IBD.
• Alteration of gut microbiota composition by dietary bioactive components or their metabolites.
• The interactions of gut microbiota and immune responses in IBD.
• Articles leveraging high throughput sequencing and multi-omics techniques are encouraged.
Keywords: dietary bioactive components, metabolites, inflammatory bowel disease, gut microbiota, immune response, IBD
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
