Research Topic

Mechanisms and Novel Treatments of Pigmentary Disorders and Skin Regeneration

About this Research Topic

Pigmentation in human skin differs individually and is regulated by more than 100 genes. Changes in melanocyte number or melanin synthesis, as well as development, transport, and transfer of melanosomes, could cause pigmentary disorders. Pigmentary disorders can be divided into hyper- and hypopigmentation. These disorders may be due to genetic and environmental factors. Pigmentary disorders are more visible on Chinese skin and are of great cosmetic concern to patients. The molecular basis, pathogenesis, and treatments of pigmentary disorders news more attention.

Skin wound healing is a complex and dynamic physiological process subdivided into four coordinated, continuous, and overlapping stages: hemostasis, inflammation, hyperplasia, and remodeling. Skin aging and rejuvenation is an eternal topic. Stem cells can be involved in these processes, and stem-cell therapy is being given the utmost research importance. How to speed up the skin healing speed, how to fight against skin aging? Stem cell therapies have broad application prospects in skin regeneration due to their ability to self-replicate, differentiate, and regulate hematopoietic and immune cells.

This Research Topic aims to cover recent, novel, basic, and translational researches in pigmentary disorders and skin regeneration. Both Original Research articles and Review articles are welcome. Preferred subtopics include but are not limited to:
• The roles of melanocytes in the pathogenesis of pigmentary disorders
• Rare pigmentary and premature aging disorders
• Advancements in the treatment of vitiligo and other pigmentary disorders
• Advanced technologies in skin re-pigmentation and skin engineering
• Novel molecular and cellular mechanisms in the development of skin aging
• Stem cells-based treatments for pigmentary disorders
• Stem cells-based treatments for skin regeneration
• System review of melanogenesis and pigmentary disorders
• System review of stem cells and stem cell-based treatments in pigmentary disorders
• System review of skin wound healing and skin regeneration


Keywords: pigmentary disorders, regeneration, aging, vitiligo, wound healing, stem cell


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Pigmentation in human skin differs individually and is regulated by more than 100 genes. Changes in melanocyte number or melanin synthesis, as well as development, transport, and transfer of melanosomes, could cause pigmentary disorders. Pigmentary disorders can be divided into hyper- and hypopigmentation. These disorders may be due to genetic and environmental factors. Pigmentary disorders are more visible on Chinese skin and are of great cosmetic concern to patients. The molecular basis, pathogenesis, and treatments of pigmentary disorders news more attention.

Skin wound healing is a complex and dynamic physiological process subdivided into four coordinated, continuous, and overlapping stages: hemostasis, inflammation, hyperplasia, and remodeling. Skin aging and rejuvenation is an eternal topic. Stem cells can be involved in these processes, and stem-cell therapy is being given the utmost research importance. How to speed up the skin healing speed, how to fight against skin aging? Stem cell therapies have broad application prospects in skin regeneration due to their ability to self-replicate, differentiate, and regulate hematopoietic and immune cells.

This Research Topic aims to cover recent, novel, basic, and translational researches in pigmentary disorders and skin regeneration. Both Original Research articles and Review articles are welcome. Preferred subtopics include but are not limited to:
• The roles of melanocytes in the pathogenesis of pigmentary disorders
• Rare pigmentary and premature aging disorders
• Advancements in the treatment of vitiligo and other pigmentary disorders
• Advanced technologies in skin re-pigmentation and skin engineering
• Novel molecular and cellular mechanisms in the development of skin aging
• Stem cells-based treatments for pigmentary disorders
• Stem cells-based treatments for skin regeneration
• System review of melanogenesis and pigmentary disorders
• System review of stem cells and stem cell-based treatments in pigmentary disorders
• System review of skin wound healing and skin regeneration


Keywords: pigmentary disorders, regeneration, aging, vitiligo, wound healing, stem cell


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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