About this Research Topic
The recent development of novel decision-making-behavioral experimental paradigms, including the use of touch-screen-based systems that allow similar tasks to be performed by humans and experimental animals, have greatly improved the translatability of research into decision-making behavior. These methodological improvements, in combination with advances in genetic and molecular tools in animals, imaging techniques in humans, and computational modeling, are now beginning to elucidate the circuit, molecular, and developmental mechanisms of decision-making behaviors, as well as their dysfunction in neurodevelopmental and psychiatric conditions. Here, our goal is to gather recent findings from multi-disciplinary studies that have helped to improve our understanding of the neural mechanisms underlying decision-making and attentional processes in humans, non-human primates, rodents, and other animals. In particular, we hope to present contemporary methodologies that will help to further improve the translatability of animal and computational decision-making-behavioral studies to real-world therapeutic applications in humans, as well as introduce novel theoretical perspectives of the neural origins of healthy and dysfunctional decision-making behavior. Finally, this Topic will highlight the importance of key developmental stages in the establishment of advantageous decision-making behavior, as well as the role of disruptive influences during these early-life stages in the occurrence of decision-making-behavioral impairments.
We welcome all article types addressing this topic. In particular, we encourage articles focusing on the following research areas:
· Novel methodologies for studying decision-making behavior in animals and humans
· Neural circuit mechanisms in flexible decision-making and attentional control
· Brain imaging insights into decision-making behavior in animals and humans
· Computational modeling of decision-making behavior
· Genetic and molecular contributions to healthy and disordered decision-making behavior
· Effects of early life events (including neurodevelopmental disorders and stress) on decision-making behavior
· Modeling of decision-making behavioral dysfunction in animals (including in neurodevelopmental and psychiatric disorder animal models)
· Therapeutic approaches to restoring impaired decision-making behavioral function
Keywords: Attention, Cognitive flexibility, Decision-making, Psychiatric disorders, Neural circuits, Neurodevelopment, Psychological stress, Reward learning
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