About this Research Topic
Research shows that mechanisms of enzyme and protease function within the context of brain disease or trauma may offer insight regarding targeted therapeutic design and application. For submissions to this Research Topic, the chemistry and biochemistry-based mechanisms described must highlight the role(s) of biological activity, protein-protein or protein-drug interactions, and chemical moieties or structures that negate/prevent key aspects of cellular degeneration. Studies that feature cell-specific targeting, development and use of machine learning or “omics”, and that address enzymatic function as a biological outcome or therapeutic target for patients are of particular interest. Injuries and diseases covered must be from at least one the following: post-hemorrhagic TBI, concussion, and sub-concussion; NDs e.g. sporadic AD, PD, as well as CTE; HIV-associated dementia and/or SARS-CoV-2 infection associated with clinical symptomology. When feasible, submissions of translational studies on animal models should aim to use non-genetic diseases and wild-type, not humanized or transgenic, animals.
This Research Topic is a call for work that presents the roles and utility of activation or inhibition of enzymes, including proteases, that play a role in neurological injury and disease progression or mitigation. Original Research, Brief Reports, Perspectives (even if conceptual), and concise Reviews will be considered. Research that includes women and minorities and/or female gendered animal models is especially welcome. Authors from globally disadvantaged backgrounds, international institutions, Historically Black Colleges and Universities, and those who identify as young investigators or "resumers", e.g. persons who were granted research or medical degrees later in life, are also strongly encouraged to submit.
Keywords: Enzyme, Protease, Brain Injury, Neurological Disease, Targeted Therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.