Myeloid cells are bone marrow-derived immune cells and comprise the lineages of monocytes, dendritic cells and granulocytes. They are the host’s first responders during acute inflammatory incidents, such as an infectious insult, but may also persist and play a pivotal role in the pathophysiology of chronic conditions, such as atherosclerosis. The advent of bulk and single-cell omics technologies (e.g. transcriptomics, epigenomics, metabolomics) together with the work of international consortia, such as the Human Cell Atlas and the Immunological Genome project have uncovered the functional diversity of myeloid cells in tissues and the periphery and have identified myeloid cell subsets that contribute to the clinical outcome of human inflammatory diseases.
Despite recent advancements in omics technologies and systems medicine computational approaches, our understanding of which molecular mechanisms dictate myeloid cell heterogeneity and impact their functionalities remains far from complete.
The goal of this Research Topic is to highlight clinically relevant molecular mechanisms or signaling pathways that drive the phenotypic heterogeneity of myeloid cells and/or their functional diversity in the context of human chronic inflammatory diseases, such as (but not limited to) respiratory, neurodegenerative and cardiovascular conditions. We welcome submissions of primary articles and case studies which have utilized omics technologies to characterize a molecular pathway in myeloid cells or reviews that summarize the progress being made in the field of myeloid cell biology using these technologies.
We welcome submissions covering, but not limited to, the following topics:
• Studies that focus on revealing myeloid cell diversity in human patients or animal models of human disease
• Studies employing in vitro systems (e.g. genetic engineering, co-cultures, organoids) to study the functions of myeloid populations at the molecular level in human disease
• Studies on the heterogeneity of granulocytes (neutrophils, eosinophils, basophils, mast cells) and their clinical relevance to human disease
• Studies on the role of signaling pathways that regulate myeloid population functionalities in the context of human disease
Myeloid cells are bone marrow-derived immune cells and comprise the lineages of monocytes, dendritic cells and granulocytes. They are the host’s first responders during acute inflammatory incidents, such as an infectious insult, but may also persist and play a pivotal role in the pathophysiology of chronic conditions, such as atherosclerosis. The advent of bulk and single-cell omics technologies (e.g. transcriptomics, epigenomics, metabolomics) together with the work of international consortia, such as the Human Cell Atlas and the Immunological Genome project have uncovered the functional diversity of myeloid cells in tissues and the periphery and have identified myeloid cell subsets that contribute to the clinical outcome of human inflammatory diseases.
Despite recent advancements in omics technologies and systems medicine computational approaches, our understanding of which molecular mechanisms dictate myeloid cell heterogeneity and impact their functionalities remains far from complete.
The goal of this Research Topic is to highlight clinically relevant molecular mechanisms or signaling pathways that drive the phenotypic heterogeneity of myeloid cells and/or their functional diversity in the context of human chronic inflammatory diseases, such as (but not limited to) respiratory, neurodegenerative and cardiovascular conditions. We welcome submissions of primary articles and case studies which have utilized omics technologies to characterize a molecular pathway in myeloid cells or reviews that summarize the progress being made in the field of myeloid cell biology using these technologies.
We welcome submissions covering, but not limited to, the following topics:
• Studies that focus on revealing myeloid cell diversity in human patients or animal models of human disease
• Studies employing in vitro systems (e.g. genetic engineering, co-cultures, organoids) to study the functions of myeloid populations at the molecular level in human disease
• Studies on the heterogeneity of granulocytes (neutrophils, eosinophils, basophils, mast cells) and their clinical relevance to human disease
• Studies on the role of signaling pathways that regulate myeloid population functionalities in the context of human disease
