Research Topic

West syndrome: New Diagnosis, Pathophysiological Investigations, and Treatment Approaches

About this Research Topic

West syndrome is an age specific epilepsy with the onset before 2 years of age. The patients typically present with hypsarrhythmia on electroencephalography, developmental/intellectual impairments or regression, and epileptic spasms. This syndrome is the common phenotype when the expanded epileptogenesis on cerebral cortices with disrupting neuronal network in deep brain structures including deep gray matters, brainstem, and cerebellum occur in young patient. Although hormonal therapy and vigabatrin are established as the treatments for West syndrome, a third of the patients are medically intractable and need neurosurgical treatment, device, and/or dietary therapy. It is critical challenge to know the pathophysiology and to develop new treatment approach in those patients. In recent years, genetic, biochemical, neurophysiological and neuroradiological approaches have developed and disclosed new aspects of pathophysiology in West syndrome. We, herein, recruit the researchers regarding advanced approaches of diagnosis, pathophysiological investigations and treatment for West syndrome.

The goal of this Research Topic is to provide new diagnostic approach, pathophysiological understanding and treatment options, by using advanced methodologies in genetic, biochemical, neurophysiology, neuroradiology. From these studies, the new genetic or biochemical knowledge will be applicable for drug developing from new pharmacological approach. The new knowledge about pathophysiology will improve treatment selection and orders from ACTH/corticosteroid, antiepileptic drugs, neurosurgery, vagus nerve stimulation and dietary therapies. Selecting appropriate surgical options (corpus callosotomy, cortical resection or disconnections), determining resection margins of cortices, and developing new surgical approach or stimulation device to disclose epileptic networks using advanced neurophysiological and neuroradiological approaches will also be discussed.

Original research, case report, narrative review, and systematic review articles are acceptable.

Suggestive researches are:

1. Genetics:

- New causative genes

- Review of causative genes in previous reports

- Applications of genetic diagnosis in clinical practice

- Genes and the pathophysiology related to development of West syndrome


2. Biochemistry:

- Biomarker of West syndrome before onset

- New biochemically treatment approaches

- Pathophysiological analysis using biochemical method

- Biomarker for selecting the treatment options


3. Neurophysiology:

- Electroencephalogram (EEG) analysis for revealing the epileptic network

- EEG analysis for improving surgical or device treatment

- Magnetoencephalography (MEG) analysis for revealing the epileptic network

- MEG analysis for improving surgical or device treatment


4. Neuroradiology:

Analyses using advanced magnetic resonance imaging (MRI) technics, functional MRI, advanced or new nuclear brain scanning or combined these methods about:

- New pathophysiological or diagnostic knowledge

- Findings which improve the outcomes of treatment, especially about neurosurgery.


5. Treatment options:

- Novel medical therapies (mechanism specific medication etc.)

- Novel surgical therapies (corpus callosotomy, disconnection, neurostimulation etc.)


Keywords: West syndrome, diagnosis, pathophysiological investigations, treatment, new


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

West syndrome is an age specific epilepsy with the onset before 2 years of age. The patients typically present with hypsarrhythmia on electroencephalography, developmental/intellectual impairments or regression, and epileptic spasms. This syndrome is the common phenotype when the expanded epileptogenesis on cerebral cortices with disrupting neuronal network in deep brain structures including deep gray matters, brainstem, and cerebellum occur in young patient. Although hormonal therapy and vigabatrin are established as the treatments for West syndrome, a third of the patients are medically intractable and need neurosurgical treatment, device, and/or dietary therapy. It is critical challenge to know the pathophysiology and to develop new treatment approach in those patients. In recent years, genetic, biochemical, neurophysiological and neuroradiological approaches have developed and disclosed new aspects of pathophysiology in West syndrome. We, herein, recruit the researchers regarding advanced approaches of diagnosis, pathophysiological investigations and treatment for West syndrome.

The goal of this Research Topic is to provide new diagnostic approach, pathophysiological understanding and treatment options, by using advanced methodologies in genetic, biochemical, neurophysiology, neuroradiology. From these studies, the new genetic or biochemical knowledge will be applicable for drug developing from new pharmacological approach. The new knowledge about pathophysiology will improve treatment selection and orders from ACTH/corticosteroid, antiepileptic drugs, neurosurgery, vagus nerve stimulation and dietary therapies. Selecting appropriate surgical options (corpus callosotomy, cortical resection or disconnections), determining resection margins of cortices, and developing new surgical approach or stimulation device to disclose epileptic networks using advanced neurophysiological and neuroradiological approaches will also be discussed.

Original research, case report, narrative review, and systematic review articles are acceptable.

Suggestive researches are:

1. Genetics:

- New causative genes

- Review of causative genes in previous reports

- Applications of genetic diagnosis in clinical practice

- Genes and the pathophysiology related to development of West syndrome


2. Biochemistry:

- Biomarker of West syndrome before onset

- New biochemically treatment approaches

- Pathophysiological analysis using biochemical method

- Biomarker for selecting the treatment options


3. Neurophysiology:

- Electroencephalogram (EEG) analysis for revealing the epileptic network

- EEG analysis for improving surgical or device treatment

- Magnetoencephalography (MEG) analysis for revealing the epileptic network

- MEG analysis for improving surgical or device treatment


4. Neuroradiology:

Analyses using advanced magnetic resonance imaging (MRI) technics, functional MRI, advanced or new nuclear brain scanning or combined these methods about:

- New pathophysiological or diagnostic knowledge

- Findings which improve the outcomes of treatment, especially about neurosurgery.


5. Treatment options:

- Novel medical therapies (mechanism specific medication etc.)

- Novel surgical therapies (corpus callosotomy, disconnection, neurostimulation etc.)


Keywords: West syndrome, diagnosis, pathophysiological investigations, treatment, new


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

30 November 2021 Abstract
31 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

30 November 2021 Abstract
31 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..