Research Topic

Y-90 Microsphere Therapy in the Era of Theranostics

About this Research Topic

Intra-arterial Yttrium-90 (Y-90) microsphere therapy, also named radioembolization, is a radionuclide therapy in which therapeutic radiation loaded micropheres are targeted to the microvasculature of hepatic tumors through intra-arterial administration. This therapeutic option can be used for both primary and metastatic liver tumors regardless of the tumor type.

The conceptual basis of this therapy is the preferential arterial blood supply of tumor cells unlike portal venous supply of healthy hepatocytes, which is a unique feature of the liver. Owing to this differential blood supply between tumoral and healthy cells, when radiation-loaded microspheres are administered transarterially, they can be specifically targeted to the tumor tissue sparing the normal liver parenchyma to a great extent. This approach allows the application of a high radiation dose to the tumor area whilst preserving the healthy liver tissue from the hazardous effects of radiation.

Given such potential advantages, Y-90 microsphere therapy has gained a wide acceptance among other therapeutic options for both primary and metastatic liver tumors in selected cases. This therapy requires a fully multidisciplinary approach which has interventional radiology and nuclear medicine as its main involved fields.

This Research Topic aims to cover the basic aspects of Y-90 microsphere therapy and to gather up-to-date information regarding the clinical applications, challenges, and future directions of this therapeutic option. We welcome manuscripts focused on but not limited to the following topics:

• The conceptual basis of ıntraarterial Y-90 microsphere therapy

• Patient selection and therapy planning for Y-90 microsphere therapy

• Technical highlights of Y-90 microsphere therapy from Interventional Radiology and/or Nuclear Medicine perspective

• Y-90 microsphere therapy as a personalized therapy option in the era of theranostics

• Dosimetric methods and radiation safety issues for Y-90 microsphere therapy

• Current therapy strategies in Y-90 microsphere therapy

• Therapy response monitoring: pitfalls and standardization

• Management of side effects and complications

• Combination of Y-90 microsphere therapy with other therapeutic modalities

• Applications of y-90 microsphere therapy to hepatocellular cancer, intrahepatic cholangiocarcinoma, and colorectal cancer or neuroendocrine tumor liver metastases

• Pros and cons of Y-90 microsphere in comparison to other radiopharmaceuticals for radioembolization


Keywords: Y-90 microsphere therapy, radioembolization, liver tumors, hepatocellular cancer, radionuclide therapy, liver metastases


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Intra-arterial Yttrium-90 (Y-90) microsphere therapy, also named radioembolization, is a radionuclide therapy in which therapeutic radiation loaded micropheres are targeted to the microvasculature of hepatic tumors through intra-arterial administration. This therapeutic option can be used for both primary and metastatic liver tumors regardless of the tumor type.

The conceptual basis of this therapy is the preferential arterial blood supply of tumor cells unlike portal venous supply of healthy hepatocytes, which is a unique feature of the liver. Owing to this differential blood supply between tumoral and healthy cells, when radiation-loaded microspheres are administered transarterially, they can be specifically targeted to the tumor tissue sparing the normal liver parenchyma to a great extent. This approach allows the application of a high radiation dose to the tumor area whilst preserving the healthy liver tissue from the hazardous effects of radiation.

Given such potential advantages, Y-90 microsphere therapy has gained a wide acceptance among other therapeutic options for both primary and metastatic liver tumors in selected cases. This therapy requires a fully multidisciplinary approach which has interventional radiology and nuclear medicine as its main involved fields.

This Research Topic aims to cover the basic aspects of Y-90 microsphere therapy and to gather up-to-date information regarding the clinical applications, challenges, and future directions of this therapeutic option. We welcome manuscripts focused on but not limited to the following topics:

• The conceptual basis of ıntraarterial Y-90 microsphere therapy

• Patient selection and therapy planning for Y-90 microsphere therapy

• Technical highlights of Y-90 microsphere therapy from Interventional Radiology and/or Nuclear Medicine perspective

• Y-90 microsphere therapy as a personalized therapy option in the era of theranostics

• Dosimetric methods and radiation safety issues for Y-90 microsphere therapy

• Current therapy strategies in Y-90 microsphere therapy

• Therapy response monitoring: pitfalls and standardization

• Management of side effects and complications

• Combination of Y-90 microsphere therapy with other therapeutic modalities

• Applications of y-90 microsphere therapy to hepatocellular cancer, intrahepatic cholangiocarcinoma, and colorectal cancer or neuroendocrine tumor liver metastases

• Pros and cons of Y-90 microsphere in comparison to other radiopharmaceuticals for radioembolization


Keywords: Y-90 microsphere therapy, radioembolization, liver tumors, hepatocellular cancer, radionuclide therapy, liver metastases


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

21 November 2021 Abstract
01 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

21 November 2021 Abstract
01 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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