About this Research Topic
Zebrafish have become a widely recognised model for a broad range of disorders, including neurodevelopmental and neurodegenerative disorders. They have high fecundity, are responsive to genetic manipulation, and especially the larvae offer a number of advantageous features, such as rapid external development, optical transparency and the ability to readily take up compounds from their environment. A long history of using zebrafish for studying neurodevelopment has provided fundamental methods for manipulation, which are being built upon, particularly in the neuroscience and chemical biology fields, ultimately facilitating or more translational studies. Furthermore, a zebrafish orthologue can be found for about 80% of disease-causing human genes. Together, these properties have led to the continued development of many interesting models for disorders affecting the nervous system and an increasing array of relevant assays.
In this Research Topic we would like to highlight recent advances in basic neuroscience from the use of zebrafish. We are particularly interested in zebrafish models, assays and tools providing insights into neurodegenerative disorders, as well as the understanding of nervous system development, function and homeostasis with relevance to understanding disorders and diseases and finding treatments.
We aim to include publications on the novel use of genetic, injury and complex nervous system disease or disorder models, novel assays and/or reporter lines of interest to the neuroscience research community. We particularly wish to underline the power zebrafish has in pharmacological research. Publications related to novel techniques which may in future be adapted to neuroscientific research are also very welcome.
Topics to be presented in this Research Topic may include, but are not limited to:
- Neurodevelopmental studies
- Novel assays to study the normal and disordered nervous system at all life stages
- Models of nervous system disorders or diseases such as neurodegeneration, brain injury, epilepsy and neurodevelopmental disorders
- Recently developed reporter lines relevant to disorders of the nervous system
- Pharmacological studies pertaining to nervous system disorders
- New techniques that may be implemented in zebrafish neuroscience research
We encourage submission of all article types.
In this Research Topic we would like to highlight recent advances in basic neuroscience from the use of zebrafish. We are particularly interested in zebrafish models, assays and tools providing insights into neurodegenerative disorders, as well as the understanding of nervous system development, function and homeostasis with relevance to understanding disorders and diseases and finding treatments.
We aim to include publications on the novel use of genetic, injury and complex nervous system disease or disorder models, novel assays and/or reporter lines of interest to the neuroscience research community. We particularly wish to underline the power zebrafish has in pharmacological research. Publications related to novel techniques which may in future be adapted to neuroscientific research are also very welcome.
Topics to be presented in this Research Topic may include, but are not limited to:
- Neurodevelopmental studies
- Novel assays to study the normal and disordered nervous system at all life stages
- Models of nervous system disorders or diseases such as neurodegeneration, brain injury, epilepsy and neurodevelopmental disorders
- Recently developed reporter lines relevant to disorders of the nervous system
- Pharmacological studies pertaining to nervous system disorders
- New techniques that may be implemented in zebrafish neuroscience research
We encourage submission of all article types.
Keywords: Genetic models, Therapeutic screening, Disease modelling, Novel methods, Behavioural models, Neurodegeneration, Neurodevelopment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
