About this Research Topic
Neurological disorders represent multiple diseases associated with the dysfunction of the nervous system, including Alzheimer’s and other dementias, Parkinson’s disease, multiple sclerosis, epilepsy, stroke and chronic pain, and impose heavy health and economic burden to the global population. Therefore, therapeutic treatment against these diseases are urgently needed. However, the mechanisms involved in neurological disorders remain partially unclear, limiting the clinical control of these diseases.
In the peripheral and central nervous system, immune cells (e.g. macrophages and T cells) and immune-like cells (e.g. astrocytes and microglia) exist alongside neurons. Under pathological conditions, neurons can release mediators to regulate the recruitment and activation of immune cells; conversely, activated immune cells can release chemokines and cytokines to modulate neuronal activities. Mounting evidence indicates such neuro-immune crosstalk regulates the pathology of neurological disorders. Thus, neuro-immune regulation has been considered as a potential target for developing novel therapeutic mechanisms against these neurological diseases.
The aims of this research topic are to update the current understanding and future directions of neuro-immune regulation of neurological disorders. We will gladly consider original researches, reviews, perspectives, and commentaries about related research on potential topics including but not limited to the following: (1) Cellular and molecular mechanisms of neuro-immune crosstalk in the pathology of neurological disorders. (2) Transcriptional and proteasomal profile of neuron and immune cells in the pathogenesis of neurological disorders. (3) Sex dimorphism in neuron- and immune cell-mediated responses in neurological disorders. (4) Novel therapeutic treatment targeting neuronal and immune cell components in the neurological disorders. We hope that interested investigators will share their valuable research on this research topic to exploit the translational potential of neuro-immune regulation in the future therapy of neurological disorders.
In the peripheral and central nervous system, immune cells (e.g. macrophages and T cells) and immune-like cells (e.g. astrocytes and microglia) exist alongside neurons. Under pathological conditions, neurons can release mediators to regulate the recruitment and activation of immune cells; conversely, activated immune cells can release chemokines and cytokines to modulate neuronal activities. Mounting evidence indicates such neuro-immune crosstalk regulates the pathology of neurological disorders. Thus, neuro-immune regulation has been considered as a potential target for developing novel therapeutic mechanisms against these neurological diseases.
The aims of this research topic are to update the current understanding and future directions of neuro-immune regulation of neurological disorders. We will gladly consider original researches, reviews, perspectives, and commentaries about related research on potential topics including but not limited to the following: (1) Cellular and molecular mechanisms of neuro-immune crosstalk in the pathology of neurological disorders. (2) Transcriptional and proteasomal profile of neuron and immune cells in the pathogenesis of neurological disorders. (3) Sex dimorphism in neuron- and immune cell-mediated responses in neurological disorders. (4) Novel therapeutic treatment targeting neuronal and immune cell components in the neurological disorders. We hope that interested investigators will share their valuable research on this research topic to exploit the translational potential of neuro-immune regulation in the future therapy of neurological disorders.
Keywords: Neurological disorder, Macrophages, microglia, astrocyte, T cells, neurons, cytokine, chemokine, mediators, sex dimorphism
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