About this Research Topic
RNA binding proteins (RBPs) play a critical role in posttranscriptional gene regulation in processes including alternative splicing, mRNA stability, polyadenylation and mRNA localization. The importance of RBPs is highlighted by their dysregulation or mutation causing a variety of cancers and neurological diseases. Thus, changes in the concentration, expression patterns, and localization of RBPs play an important role in tailoring gene expression to cellular conditions. Cell-signalling induced reversible modifications can alter RBP activity including concentration and cellular localization. Proteome-wide mass spectrometry studies highlight that RBPs are modified by the addition of many chemical groups. Understanding how these cell-signalling induced reversible modifications regulate RBP function and in turn posttranscriptional gene regulation will enhance our understanding of how gene expression patterns are regulated in response to various stimuli. These studies will also lead to the discovery of novel pathways and enzymes involved in RBP regulation and provide candidates for therapeutic targets for rational drug design.
Recent studies highlight that many RBPs are modified by the addition of posttranslational modifications including phosphates, acetates, glycosylated, and ubiquitin. However, the roles of these modifications in RBP function, as well as enzymes that add and remove these chemical groups could benefit from a further understanding. This Research Topic aims to collect articles that report studies on posttranslational modifications in RNA binding protein function. These findings will enhance our understanding of how cell signaling pathways regulate gene expression and in turn unravel novel enzyme and pathways involved these processes which may serve as therapeutic targets for rational drug design for diseases linked to aberrant gene expression.
This collection welcomes Original Research, Review, Mini Review, Methods, and Perspectives on studies describing identification and characterization of posttranslational modifications in RNA binding protein function. Areas of interest could include, but are not limited to:
• Proteome wide discoveries of PTM’s in RNA binding proteins
• Optimized methods for identification of PTMs in RNA binding proteins
• Identification and characterization of PTM(s) in an RNA binding protein
• Bioinformatics analyses of post translationally modified residues in RNA binding proteins
Keywords: PTM, RNA Binding Protein, Postranscriptional Gene Regulation, RBP, mRNA, RNA, Proteomics
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