Research Topic

Molecular Mechanisms and the Impact of Mitochondrial Stress Response Pathways in Aging

About this Research Topic

Mitochondria are essential organelles participating in numerous cellular processes such as energy harvesting, intermediate metabolism, calcium buffering, apoptosis and immune response. Although mitochondria possess their own genome, most mitochondrial proteins are encoded in the nucleus. Therefore, the expression of the mitochondrial proteome requires tight coordination between the two genomes to adapt to changes in the cellular milieu and extra-cellular environment. To cope with these challenges, multiple mitochondria stress response (MSR) pathways such as the mitochondrial unfolded protein response (UPRmt), mitophagy, and the unfolded protein response activated by the mistargeting of proteins (UPRam) have evolved. Recent studies indicate that activation of these MSR pathways not only restores mitochondrial function, but also generally preserves health during aging and delays the onset of age-related-diseases.

The purpose of this Research Topic is to tackle the molecular mechanisms on how these MSR pathways are regulated, and how genetic or pharmacological interventions of these pathways could impact key health signatures and aging-related diseases.

This Research Topic welcomes papers addressing, but not limited to, the following topics:

• The role of mitochondrial stress response pathways in aging and longevity

• Mechanisms of how mitochondrial stress response pathways are regulated

• Changes of the mitochondrial stress response pathways in response to aging and the onset of aging-related diseases

• Effects of genetic or pharmacological interventions of mitochondrial stress response pathways on aging, health signatures and aging-related diseases

• Mechanisms of the pharmacological interventions regulating the mitochondrial stress response pathways


Keywords: Mitochondrial Stress, Aging, Metabolism, Immune Responses, pharmacological, Longevity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Mitochondria are essential organelles participating in numerous cellular processes such as energy harvesting, intermediate metabolism, calcium buffering, apoptosis and immune response. Although mitochondria possess their own genome, most mitochondrial proteins are encoded in the nucleus. Therefore, the expression of the mitochondrial proteome requires tight coordination between the two genomes to adapt to changes in the cellular milieu and extra-cellular environment. To cope with these challenges, multiple mitochondria stress response (MSR) pathways such as the mitochondrial unfolded protein response (UPRmt), mitophagy, and the unfolded protein response activated by the mistargeting of proteins (UPRam) have evolved. Recent studies indicate that activation of these MSR pathways not only restores mitochondrial function, but also generally preserves health during aging and delays the onset of age-related-diseases.

The purpose of this Research Topic is to tackle the molecular mechanisms on how these MSR pathways are regulated, and how genetic or pharmacological interventions of these pathways could impact key health signatures and aging-related diseases.

This Research Topic welcomes papers addressing, but not limited to, the following topics:

• The role of mitochondrial stress response pathways in aging and longevity

• Mechanisms of how mitochondrial stress response pathways are regulated

• Changes of the mitochondrial stress response pathways in response to aging and the onset of aging-related diseases

• Effects of genetic or pharmacological interventions of mitochondrial stress response pathways on aging, health signatures and aging-related diseases

• Mechanisms of the pharmacological interventions regulating the mitochondrial stress response pathways


Keywords: Mitochondrial Stress, Aging, Metabolism, Immune Responses, pharmacological, Longevity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

23 November 2021 Abstract
23 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

23 November 2021 Abstract
23 March 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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