Metabolic syndrome (MetS) refers to a clustering of risk factors related to cardiovascular disease and type 2 diabetes including obesity, dyslipidemia, insulin resistance, and hypertension. Chronic low-grade inflammation and altered immune response are also associated with the pathophysiology of MetS. This state of chronic activation of pro-inflammatory pathways is well established in the link between obesity and insulin resistance.
Diet is a major modifiable risk factor for the development of MetS for which nutritional deficiency or insufficiency, as well as overnutrition, are associated with changes in immune functions. There is significant cross-talk between immune and metabolic systems that are involved in supporting metabolic health. Moreover, the microbiome represents a key modulator of both immune response and metabolic functions. The modulation of immune function through the microbiome presents another interplay between diet, immunity, and metabolic health.
In this Research Topic, we will aim to discuss aspects of nutrition and dietary components that influence immune function in the context of the MetS. Nutrition plays an important role in mitigating inflammation and cardiovascular risk factors. Understanding the link between nutrition and the immune changes that occur in MetS will facilitate the development of targeted lifestyle interventions aimed at the prevention and treatment of risk factors and metabolic dysfunction.
Authors are welcome to submit original research or review articles on the following topics (not limited to):
1. Role of bioactives, functional foods, or dietary ingredients on the potential modulation of:
(i) Chronic low-grade inflammation
(ii) Pro-inflammatory processes in the liver, gut, and adipose tissue
(iii) Immune alterations in obesity and its associated metabolic dysfunctions (e.g. insulin resistance, dyslipidemia etc.)
2. Dietary strategies to mitigate systemic inflammation in the context of metabolic syndrome
3. The importance of nutrition to support immune and metabolic health in the context of metabolic syndrome
Metabolic syndrome (MetS) refers to a clustering of risk factors related to cardiovascular disease and type 2 diabetes including obesity, dyslipidemia, insulin resistance, and hypertension. Chronic low-grade inflammation and altered immune response are also associated with the pathophysiology of MetS. This state of chronic activation of pro-inflammatory pathways is well established in the link between obesity and insulin resistance.
Diet is a major modifiable risk factor for the development of MetS for which nutritional deficiency or insufficiency, as well as overnutrition, are associated with changes in immune functions. There is significant cross-talk between immune and metabolic systems that are involved in supporting metabolic health. Moreover, the microbiome represents a key modulator of both immune response and metabolic functions. The modulation of immune function through the microbiome presents another interplay between diet, immunity, and metabolic health.
In this Research Topic, we will aim to discuss aspects of nutrition and dietary components that influence immune function in the context of the MetS. Nutrition plays an important role in mitigating inflammation and cardiovascular risk factors. Understanding the link between nutrition and the immune changes that occur in MetS will facilitate the development of targeted lifestyle interventions aimed at the prevention and treatment of risk factors and metabolic dysfunction.
Authors are welcome to submit original research or review articles on the following topics (not limited to):
1. Role of bioactives, functional foods, or dietary ingredients on the potential modulation of:
(i) Chronic low-grade inflammation
(ii) Pro-inflammatory processes in the liver, gut, and adipose tissue
(iii) Immune alterations in obesity and its associated metabolic dysfunctions (e.g. insulin resistance, dyslipidemia etc.)
2. Dietary strategies to mitigate systemic inflammation in the context of metabolic syndrome
3. The importance of nutrition to support immune and metabolic health in the context of metabolic syndrome