Research Topic

New insights in pathophysiological and physiological tissue adaptation during ischemia and reperfusion

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Although a proper blood flow is essential for tissue and organ function ischemic periods may occur under physiological conditions and also under pathophysiological conditions in which blood flow is interrupted due to thrombotic events. Therefore, each organ has to develop strategies to maintain small ischemic ...

Although a proper blood flow is essential for tissue and organ function ischemic periods may occur under physiological conditions and also under pathophysiological conditions in which blood flow is interrupted due to thrombotic events. Therefore, each organ has to develop strategies to maintain small ischemic periods whereas under pathophysiological conditions revascularization can be achieved by various approaches. Unfortunately, reperfusion of ischemic tissue often results not only in revascularization and salvage of survived tissue material but also in additive stress, called the reperfusion injury. Nevertheless, recent findings have indicated novel strategies of tissues by which brief periods of ischemic events may trigger tissue protection. These mechanisms are summarized under the term pre-conditioning, per-conditioning, post-conditioning, and remote conditioning. The underlying mechanisms by which tissues can be protected against the fatal consequence of ischemia and reperfusion are not fully understood but the high relevance of these phenomenon for organ survival attracts many researcher to identify potential targets that can be used to improve the outcome of stroke, myocardial infarction, lung embolism and the consequence of ischemia for gut and kidney to give some examples.
The current Frontiers Topic is aimed to summarize review and original contributions that focus on mechanism responsible for reperfusion-induced damage in divergent tissues and to give the reader an overview across the common and tissue-specific effects of this pathophysiological relevant field of physiology and biology. Studies are also welcome that focus on molecular mechanisms that deal with conditioning effects as such mechanisms are probably most important for our understanding of physiological behaviour of tissues during brief periods of ischemia that may occur occasionally, but also likely candidates to develop novel protective strategies in medical procedures.


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